| UniProt/SwissProt ID: | PKR2_HUMAN |
| Description: | prokineticin receptor 2 [Source:HGNC Symbol;Acc:15836] |
| Location: | chr20 p12.3 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T374 | TNGVPtTEEVD | PhosphoSitePlus | |
| T369 | DLDLRtNGVPT | PhosphoSitePlus | |
| S362 | RGSKSsADLDL | PhosphoSitePlus | |
| Dephosphorylation site |
| PKR2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000217270 | R268G | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000217270 | D112Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000217270 | V331M | COSMIC | Pancreatic Cancer | ENSP00000217270 | R353H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000217270 | M341I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000217270 | L95P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000217270 | S138F | COSMIC | Skin Cancer | 21984974 | ENSP00000217270 | S23F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000217270 | R85C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000217270 | G293S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000217270 | M165I | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000217270 | C279S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000217270 | R298C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PKR2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PKR2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PROK2_HUMAN | PKR2_HUMAN | ligand -> receptor | HPMR |
| PROK1_HUMAN | PKR2_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| PKR2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004983 | neuropeptide Y receptor activity | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007623 | circadian rhythm | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |