Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDGFA_HUMAN
Description:platelet-derived growth factor alpha polypeptide [Source:HGNC Symbol;Acc:8799]
Location:chr7 p22.3
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S108YEIPRsQVDPTPDGFPhosphoSitePlus
S114QVDPTsANFLIPDGFPhosphoSitePlus
T113SQVDPtSANFLPDGFPhosphoSitePlus

Dephosphorylation site
PDGFA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000346508E76KCOSMICHead and Neck Cancer21798893

Differential expressed protein
PDGFA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDGFA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDGFA_HUMANPGFRA_HUMANligand -> receptorHPMR
PDGFA_HUMANPGFRA_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05214Glioma
hsa05215Prostate cancer
hsa04060Cytokine-cytokine receptor interaction
hsa05218Melanoma
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa04010MAPK signaling pathway
hsa05166HTLV-I infection
hsa05202Transcriptional misregulation in cancer
hsa04510Focal adhesion
hsa04540Gap junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0030031cell projection assemblyIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIMPbiological_process
GO:0030168platelet activationTASbiological_process
GO:0042060wound healingIEAbiological_process
GO:0001942hair follicle developmentISSbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0045740positive regulation of DNA replicationIDAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatISSbiological_process
GO:0050919negative chemotaxisIDAbiological_process
GO:0043499eukaryotic cell surface bindingIDAmolecular_function
GO:0001942hair follicle developmentIEAbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0005902microvillusISScellular_component
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0010544negative regulation of platelet activationIDAbiological_process
GO:0010512negative regulation of phosphatidylinositol biosynIDAbiological_process
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0032526response to retinoic acidIEAbiological_process
GO:0035793positive regulation of metanephric mesenchymal celIDAbiological_process
GO:0060683regulation of branching involved in salivary glandIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0043406positive regulation of MAP kinase activityIDAbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0043498cell surface bindingIDAmolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0009611response to woundingIDAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0048008platelet-derived growth factor receptor signaling IDAbiological_process
GO:0009790embryo developmentTASbiological_process
GO:0014910regulation of smooth muscle cell migrationIDAbiological_process
GO:0051897positive regulation of protein kinase B signaling IDAbiological_process
GO:0060683regulation of branching involved in salivary glandISSbiological_process
GO:0031954positive regulation of protein autophosphorylationIDAbiological_process
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0030036actin cytoskeleton organizationISSbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0005902microvillusIEAcellular_component
GO:0048839inner ear developmentIEAbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0005518collagen bindingIDAmolecular_function
GO:0048286lung alveolus developmentISSbiological_process
GO:0043588skin developmentISSbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0050730regulation of peptidyl-tyrosine phosphorylationISSbiological_process
GO:0009887organ morphogenesisISSbiological_process
GO:0048286lung alveolus developmentIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0001775cell activationTASbiological_process
GO:0042060wound healingTASbiological_process
GO:0030031cell projection assemblyISSbiological_process
GO:0048146positive regulation of fibroblast proliferationIDAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0043588skin developmentIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0001525angiogenesisISSbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0014068positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0048407platelet-derived growth factor bindingIPImolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0005161platelet-derived growth factor receptor bindingIDAmolecular_function
GO:0010035response to inorganic substanceIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0032956regulation of actin cytoskeleton organizationTASbiological_process