Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDE4D_HUMAN
Description:phosphodiesterase 4D, cAMP-specific [Source:HGNC Symbol;Acc:8783]
Location:chr5 q12.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S54SQRREsFLYRSPRKACAHPRD
S212EVEIPsPTQKEHPRD
S190SQRREsFLYRSphosphoELM; SysPTM
S239LMHSSsLTNSSHPRD
S18GSGEGsDSAGGPhosphoSitePlus; phosphoELM; RegPhos
S71SPKSMsRNSSIHPRD
S365PMSQIsGVKKLPhosphoSitePlus
S460TKKVTsSGVLLHPRD
S190SQRREsFLYRSUCR1PhosphoSitePlus; SysPTM
S202SDYDLsPKSMSUCR1PhosphoSitePlus; SysPTM
S348EVEIPsPTQKEUCR2PhosphoSitePlus
S35LDPMTsPGSGLHPRD
S618EKDSGsQVEEDHPRD
S75MSRNSsIASDIHPRD
S252QDRAPsKRSPMPhosphoSitePlus
S20GEGSDsAGGATPhosphoSitePlus; phosphoELM
S202SDYDLsPKSMSphosphoELM; RegPhos; SysPTM
S596TKKVTsSGVLLPDEase_IPhosphoSitePlus
S214NSSIAsDIHGDphosphoELM; RegPhos
S299LQTRHsVSEMAUCR2PhosphoSitePlus
S74SMSRNsSIASDHPRD
T25SAGGAtLKAPKPhosphoSitePlus; RegPhos
S69DLSPKsMSRNSHPRD
S301TRHSVsEMASNUCR2PhosphoSitePlus
S348EVEIPsPTQKEphosphoELM; RegPhos
S197LYRSDsDYDLSphosphoELM; RegPhos; SysPTM
S597KKVTSsGVLLLPDEase_IPhosphoSitePlus
S96AQVLAsLRTVRHPRD
S197LYRSDsDYDLSUCR1PhosphoSitePlus; SysPTM
S190SQRREsFLYRSPKACaRegPhos; SysPTM
S61LYRSDsDYDLSHPRD
S13PFRRHsWICFDPRKACAHPRD
S616DTEKDsGSQVEHPRD
Y199RSDSDyDLSPKUCR1PhosphoSitePlus
S66SDYDLsPKSMSHPRD
S362KKRPMsQISGVPhosphoSitePlus
T88DDLIVtPFAQVHPRD
S375LMHSSsLTNSSPhosphoSitePlus
S38MTSPGsGLILQHPRD
S606LLDNYsDRIQVPDEase_IPhosphoSitePlus

Dephosphorylation site
PDE4D_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353152E622ACOSMICBreast Cancer

Differential expressed protein
PDE4D_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDE4D_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPDE4D_HUMANkinase -> substrateRegPhos
KPCA_HUMANPDE4D_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00230Purine metabolism
hsa05032Morphine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030593neutrophil chemotaxisIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0008144drug bindingIPImolecular_function
GO:0006939smooth muscle contractionIEAbiological_process
GO:0006198cAMP catabolic processIEAbiological_process
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityIEAmolecular_function
GO:00041153',5'-cyclic-AMP phosphodiesterase activityTASmolecular_function
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityNASmolecular_function
GO:0097110scaffold protein bindingIPImolecular_function
GO:0050900leukocyte migrationIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005815microtubule organizing centerIEAcellular_component
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0035264multicellular organism growthIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0030552cAMP bindingIDAmolecular_function
GO:0007568agingIEAbiological_process
GO:0061028establishment of endothelial barrierISSbiological_process


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