| UniProt/SwissProt ID: | PDE4B_HUMAN |
| Description: | phosphodiesterase 4B, cAMP-specific [Source:HGNC Symbol;Acc:8781] |
| Location: | chr1 p31.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S272 | SGNQVsEYISN | RegPhos | |
| S133 | SQRREsFLYRS | PRKACA | HPRD |
| S125 | LYRSDsDYDLS | HPRD | |
| S133 | SQRREsFLYRS | PKA_group | phosphoELM; RegPhos |
| S133 | SQRREsFLYRS | PhosphoSitePlus; phosphoELM | |
| S133 | SQRREsFLYRS | PKACa | RegPhos |
| Y142 | RSDSDyDLSPK | PhosphoSitePlus | |
| S145 | SDYDLsPKAMS | PhosphoSitePlus; HPRD | |
| S197 | TSNKRsPAASQ | PhosphoSitePlus | |
| S201 | RSPAAsQPPVS | PhosphoSitePlus | |
| Y549 | LLLDNyTDRIQ | PDEase_I | PhosphoSitePlus |
| Y215 | PQEESyQKLAM | DUF2869 | PhosphoSitePlus |
| S140 | LYRSDsDYDLS | PhosphoSitePlus; HPRD | |
| S214 | NPQEEsYQKLA | DUF2869 | PhosphoSitePlus |
| Y274 | NQVSEyISNTF | RegPhos | |
| S520 | LATDMsKHMSL | PDEase_I | PhosphoSitePlus |
| S659 | SMIPQsPSPPL | PhosphoSitePlus | |
| S732 | ATEDKsPVDT | RegPhos | |
| S732 | ATEDKsPV | HPRD | |
| S130 | SDYDLsPKAMS | HPRD | |
| T184 | VRNNFtILTNL | RegPhos | |
| Dephosphorylation site |
| PDE4B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000332116 | L565V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000392947 | E282* | COSMIC | Skin Cancer | 21984974 | ENSP00000392947 | S703F | COSMIC | Skin Cancer | 21984974 | ENSP00000332116 | S718F | COSMIC | Skin Cancer | 21984974 | ENSP00000392947 | C547Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000392947 | A3E | COSMIC | Hepatocellular Carcinoma | ENSP00000392947 | L550V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000332116 | E93Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000332116 | E297* | COSMIC | Skin Cancer | 21984974 | ENSP00000332116 | C562Y | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| PDE4B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PDE4B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | PDE4B_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | PDE4B_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00230 | Purine metabolism |
| hsa05032 | Morphine addiction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001780 | neutrophil homeostasis | IEA | biological_process |
| GO:0006198 | cAMP catabolic process | IEA | biological_process |
| GO:0071944 | cell periphery | IEA | cellular_component |
| GO:0030593 | neutrophil chemotaxis | IEA | biological_process |
| GO:0035690 | cellular response to drug | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | IEA | molecular_function |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0050900 | leukocyte migration | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0071222 | cellular response to lipopolysaccharide | IEA | biological_process |