Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDE4B_HUMAN
Description:phosphodiesterase 4B, cAMP-specific [Source:HGNC Symbol;Acc:8781]
Location:chr1 p31.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S272SGNQVsEYISNRegPhos
S133SQRREsFLYRSPRKACAHPRD
S125LYRSDsDYDLSHPRD
S133SQRREsFLYRSPKA_groupphosphoELM; RegPhos
S133SQRREsFLYRSPhosphoSitePlus; phosphoELM
S133SQRREsFLYRSPKACaRegPhos
Y142RSDSDyDLSPKPhosphoSitePlus
S145SDYDLsPKAMSPhosphoSitePlus; HPRD
S197TSNKRsPAASQPhosphoSitePlus
S201RSPAAsQPPVSPhosphoSitePlus
Y549LLLDNyTDRIQPDEase_IPhosphoSitePlus
Y215PQEESyQKLAMDUF2869PhosphoSitePlus
S140LYRSDsDYDLSPhosphoSitePlus; HPRD
S214NPQEEsYQKLADUF2869PhosphoSitePlus
Y274NQVSEyISNTFRegPhos
S520LATDMsKHMSLPDEase_IPhosphoSitePlus
S659SMIPQsPSPPLPhosphoSitePlus
S732ATEDKsPVDTRegPhos
S732ATEDKsPVHPRD
S130SDYDLsPKAMSHPRD
T184VRNNFtILTNLRegPhos

Dephosphorylation site
PDE4B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000332116L565VCOSMICOvarian Cancer21720365
ENSP00000392947E282*COSMICSkin Cancer21984974
ENSP00000392947S703FCOSMICSkin Cancer21984974
ENSP00000332116S718FCOSMICSkin Cancer21984974
ENSP00000392947C547YCOSMICHead and Neck Cancer21798893
ENSP00000392947A3ECOSMICHepatocellular Carcinoma
ENSP00000392947L550VCOSMICOvarian Cancer21720365
ENSP00000332116E93QCOSMICHead and Neck Cancer21798893
ENSP00000332116E297*COSMICSkin Cancer21984974
ENSP00000332116C562YCOSMICHead and Neck Cancer21798893

Differential expressed protein
PDE4B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDE4B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANPDE4B_HUMANkinase -> substrateHPRD
ZAGL2_HUMANPDE4B_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00230Purine metabolism
hsa05032Morphine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001780neutrophil homeostasisIEAbiological_process
GO:0006198cAMP catabolic processIEAbiological_process
GO:0071944cell peripheryIEAcellular_component
GO:0030593neutrophil chemotaxisIEAbiological_process
GO:0035690cellular response to drugIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:00041153',5'-cyclic-AMP phosphodiesterase activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0050900leukocyte migrationIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0071222cellular response to lipopolysaccharideIEAbiological_process


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