Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDE3B_HUMAN
Description:phosphodiesterase 3B, cGMP-inhibited [Source:HGNC Symbol;Acc:8779]
Location:chrHG873_PATCH p15.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S299RSSCVsLGETAPhosphoSitePlus
S310ASYYGsCKIFRPhosphoSitePlus
Y565NTPDFyQQLRNPhosphoSitePlus
S371LLTDPsLPPQVPhosphoSitePlus
T769HNGCGtGNETDPhosphoSitePlus
S26GSPPEsLRNGYPhosphoSitePlus
S73QPRRCsPFCRAPhosphoSitePlus
T625QQEEEtEKKDSRegPhos
S295RPRRRsSCVSLPhosphoSitePlus
S379PQVISsLRSISPhosphoSitePlus
S554VILQRsLGNAPPhosphoSitePlus
S323SLPCIsREQMIPhosphoSitePlus
T303VSLGEtAASYYPhosphoSitePlus
S588MLKYVsTSESDPhosphoSitePlus
S296PRRRSsCVSLGPhosphoSitePlus
S393GAFSGsCRPKIPhosphoSitePlus
Y586HQMLKyVSTSEPhosphoSitePlus
S571QQLRNsDSNLCPhosphoSitePlus
Y751LHAVWyLTTRPPDEase_IPhosphoSitePlus
S442QLRRSsGTSGLPhosphoSitePlus; phosphoELM; SysPTM
S378PPQVIsSLRSIPhosphoSitePlus
T561GNAPNtPDFYQPhosphoSitePlus
T773GTGNEtDSDGRPhosphoSitePlus
S442QLRRSsGTSGLAKT1HPRD; RegPhos; SysPTM
S318IFRRPsLPCISPhosphoSitePlus; phosphoELM
S318IFRRPsLPCISAKT1HPRD; RegPhos
S295RPRRRsSCVSLAKT1HPRD; RegPhos
S318IFRRPsLPCISPKACaRegPhos
S318IFRRPsLPCISPKA_groupphosphoELM; RegPhos
S318IFRRPsLPCISPRKACAHPRD
T444RRSSGtSGLLPPhosphoSitePlus; HPRD; phosphoELM
T487NSNLLtIPKQRPhosphoSitePlus

Dephosphorylation site
PDE3B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282096E686QBIOMARTBreast Cancer21930507, 21930502
ENSP00000282096F832LCOSMICHead and Neck Cancer21798893
ENSP00000282096D668NCOSMICHead and Neck Cancer21798893
ENSP00000282096S432NCOSMICSkin Cancer21984974
ENSP00000282096N1042HBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000282096D333NCOSMICSkin Cancer21984974

Differential expressed protein
PDE3B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDE3B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANPDE3B_HUMANkinase -> substrateHPRD
ZAGL2_HUMANPDE3B_HUMANkinase -> substrateRegPhos
AKT1_HUMANPDE3B_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04914Progesterone-mediated oocyte maturation
hsa00230Purine metabolism
hsa04910Insulin signaling pathway
hsa05032Morphine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043951negative regulation of cAMP-mediated signalingICbiological_process
GO:0007162negative regulation of cell adhesionIMPbiological_process
GO:0031018endocrine pancreas developmentIEAbiological_process
GO:0043422protein kinase B bindingISSmolecular_function
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityTASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0033629negative regulation of cell adhesion mediated by iICbiological_process
GO:0050995negative regulation of lipid catabolic processIMPbiological_process
GO:0016525negative regulation of angiogenesisIMPbiological_process
GO:0032045guanyl-nucleotide exchange factor complexIDAcellular_component
GO:0005794Golgi apparatusISScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0005783endoplasmic reticulumISScellular_component
GO:0050796regulation of insulin secretionIEAbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0032869cellular response to insulin stimulusISSbiological_process
GO:0004119cGMP-inhibited cyclic-nucleotide phosphodiesteraseTASmolecular_function
GO:0016020membraneIDAcellular_component
GO:0001525angiogenesisIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0006198cAMP catabolic processIEPbiological_process
GO:0046872metal ion bindingIEAmolecular_function


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