| UniProt/SwissProt ID: | PDCD5_HUMAN |
| Description: | programmed cell death 5 [Source:HGNC Symbol;Acc:8764] |
| Location: | chr19 q13.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y80 | IQMARyGQLSE | dsDNA_bind; Terminase_4 | PhosphoSitePlus |
| Y125 | DEDDDy_____ | PhosphoSitePlus | |
| S119 | RKVMDsDEDDD | Terminase_4 | PhosphoSitePlus |
| S119 | RKVMDsDEDD | phosphoELM | |
| Y73 | KAVENyLIQMA | dsDNA_bind; Terminase_4 | PhosphoSitePlus |
| Dephosphorylation site |
| PDCD5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000221784 | D122H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000221784 | R55S | COSMIC | Lung Cancer | ENSP00000221784 | E85D | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000221784 | Non-small cell lung carcinoma | Metastasis | cell line | Up | 17537172 | ENSP00000221784 | Renal Cancer | Normal vs. Cancer | tissue | Down | 0.36 | 19610612 |
| Hyperphosphorylation site |
| PDCD5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK4_HUMAN | PDCD5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PDCD5_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006917 | induction of apoptosis | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |