Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDC6I_HUMAN
Description:programmed cell death 6 interacting protein [Source:HGNC Symbol;Acc:8766]
Location:chr3 p22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y258QANAEyHQSILBRO1PhosphoSitePlus
Y319DNDFIyHDRVPSRCHPRD
S730PAYQSsPAGGHPhosphoSitePlus; HPRD; phosphoELM
S718IAREPsAPSIPPhosphoSitePlus
Y39EEQAQyCRAAEBRO1PhosphoSitePlus
T738GGHAPtPPTPAPhosphoSitePlus; HPRD; phosphoELM
Y294SRYDEyVNVKDBRO1PhosphoSitePlus
S366VSVQQsLAAYNBRO1PhosphoSitePlus
T741APTPPtPAPRTPhosphoSitePlus; HPRD; phosphoELM
Y370QSLAAyNQRKABRO1PhosphoSitePlus
S729TPAYQsSPAGGHPRD; phosphoELM
S712KDLQQsIAREPPhosphoSitePlus; HPRD
Y727IPTPAyQSSPAPhosphoSitePlus; HPRD; phosphoELM
T724APSIPtPAYQSPhosphoSitePlus
Y485PSNELyKPLRAALIX_LYPXL_bndPhosphoSitePlus
T186PDTVGtLSLIMBRO1PhosphoSitePlus
Y223NQAADyFGDAFBRO1PhosphoSitePlus
Y319DNDFIyHDRVPBRO1PhosphoSitePlus

Dephosphorylation site
PDC6I_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000307387L308VCOSMICOvarian Cancer21720365
ENSP00000307387A98VCOSMICMelanoma
ENSP00000307387D591GCOSMICCentral Nervous System Neoplasms21817013

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000307387Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineUp1316319398
ENSP00000307387Hepatocellular CarcinomaMetastasiscell lineUp1.919016532
ENSP00000307387Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueDown0.4519329653
ENSP00000307387Breast CancerNormal vs. Cancercell lineUp1.920052998
ENSP00000307387Breast CancerNormal vs. Cancercell lineDown0.9320052998
ENSP00000307387Breast CancerMetastasiscell lineDown0.520052998
ENSP00000307387NonmelanomaNormal vs. Cancercell lineDown0.719243805
ENSP00000307387Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.319714814

Hyperphosphorylation site
PDC6I_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANPDC6I_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0005815microtubule organizing centerIEAcellular_component
GO:0046983protein dimerization activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007049cell cycleIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0048306calcium-dependent protein bindingIPImolecular_function
GO:0042470melanosomeIEAcellular_component
GO:0015031protein transportIEAbiological_process


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