Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PCBP2_HUMAN
Description:poly(rC) binding protein 2 [Source:HGNC Symbol;Acc:8648]
Location:chr12 q13.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T15LNVTLtIRLLMHPRD
S171MLETLsQSPPKHPRD
Y182GVTIPyRPKPSPhosphoSitePlus; HPRD; phosphoELM
S169VVMLEsPPKGVHPRD
S364TGGMGsS____PhosphoSitePlus
T175PPKGVtIPYRPHPRD
S365GGMGSs_____PhosphoSitePlus
T169VVMLEtLSQSPHPRD
S330TGGMGHPRD
T15LNVTLtIRLLMKH_1PhosphoSitePlus
T213SFPHTtPSMCLPhosphoSitePlus
S183YRPKPsSSPVIHPRD
T179PPKGVtIPYRPPhosphoSitePlus
S267SGIESsSPEVKHPRD
T231PLEAYtIQGQYPhosphoSitePlus
Y178GVTIPyRPKPSHPRD
S365TGGMGHPRD
S173ETLSQsPPKGVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S289SAQTTsHELTIKH_1PhosphoSitePlus
S185PKPSSsPVIFAHPRD
Y232TIQGQyAIPQPHPRD
S107LVVPAsQCGSLKH_1PhosphoSitePlus
S361TGGMGHPRD
T202QDRYStGSDSAPhosphoSitePlus
S271SGIESsSPEVKPhosphoSitePlus; HPRD; phosphoELM
S236SGIESsSPEVKHPRD
S268GIESSsPEVKGHPRD
S187YRPKPsSSPVIPhosphoSitePlus; HPRD; phosphoELM
S272GIESSsPEVKGPhosphoSitePlus; HPRD; phosphoELM
S50ARINIsEGNCPKH_1PhosphoSitePlus
S184RPKPSsSPVIFHPRD
S188RPKPSsSPVIFPhosphoSitePlus; HPRD; phosphoELM
S189PKPSSsPVIFAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y230PPLEAyTIQGQPhosphoSitePlus
S237GIESSsPEVKGHPRD
Y236TIQGQyAIPQPPhosphoSitePlus; HPRD; phosphoELM
T13GGLNVtLTIRLHPRD
Y201TIQGQyAIPQPHPRD
T99SRPPVtLRLVVKH_1PhosphoSitePlus
Y278PEVKGyWGLDAPhosphoSitePlus

Dephosphorylation site
PCBP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000352438Q108*COSMICHead and Neck Cancer21798893
ENSP00000352438R306HCOSMICCentral Nervous System Neoplasms21817013

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000408949Breast CancerTreatment (none vs. SEL1L treatment)cell lineDown0.215880780
ENSP00000408949chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineUp1.320417730
ENSP00000408949Renal CancerNormal vs. CancertissueUp3.119610612
ENSP00000408949Pancreatic CancerTreatment (none vs. IL-1 treatment)cell lineUp1.819513556

Hyperphosphorylation site
PCBP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ARAF_HUMANPCBP2_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANPCBP2_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANPCBP2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PCBP2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019899enzyme bindingIPImolecular_function
GO:0050687negative regulation of defense response to virusIMPbiological_process
GO:0043161proteasomal ubiquitin-dependent protein catabolic IMPbiological_process
GO:0008380RNA splicingTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0000398mRNA splicing, via spliceosomeTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0003723RNA bindingIEAmolecular_function
GO:0005634nucleusNAScellular_component
GO:0051607defense response to virusIEAbiological_process
GO:0016071mRNA metabolic processNASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0032480negative regulation of type I interferon productioTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0030529ribonucleoprotein complexIEAcellular_component
GO:0005737cytoplasmNAScellular_component


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