Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PASK_HUMAN
Description:PAS domain containing serine/threonine kinase [Source:HGNC Symbol;Acc:17270]
Location:chr2 q37.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S106PRGSVsCCSLLPhosphoSitePlus
S1323PRLLTs_____PhosphoSitePlus
S1277ESGVLsAASLEPhosphoSitePlus; HPRD; phosphoELM
S60SRLCQsRTALSPhosphoSitePlus
T1322DPRLLtS____PhosphoSitePlus
S333EAAPVsGYRASHPRD; phosphoELM
T1165YTFCGtIEYCAPkinasePhosphoSitePlus
S104SEPRGsVSCCSPhosphoSitePlus
S1000YSQKYsTMSPLPkinasePhosphoSitePlus
S524PVAIEsPGQDLPhosphoSitePlus; HPRD; phosphoELM
S670QLSQLsLAGALPhosphoSitePlus
Y389LIPGFySYMDLPAS_9PhosphoSitePlus
S1289GNRSLsDVAQAHPRD; phosphoELM
S55RRNGLsRLCQSPhosphoSitePlus
S949RLFLAsLPGSTPhosphoSitePlus; HPRD
S390IPGFYsYMDLAPAS_9PhosphoSitePlus
T1001SQKYStMSPLGPkinasePhosphoSitePlus
S1057EIAILsRVEHAHPRD
S1003KYSTMsPLGSGPkinasePhosphoSitePlus
T1165YTFCGtIEYCARegPhos
T1161GKLFYtFCGTIPkinasePhosphoSitePlus
S116LRGLSsGWSSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S533DLLGEsRSEPVPhosphoSitePlus; HPRD; phosphoELM
T874VQVTStPVIVMPhosphoSitePlus
S953ASLPGsTHSTAHPRD
S667IKEQLsQLSLAPhosphoSitePlus
T954SLPGStHSTAAPhosphoSitePlus
T1161GKLFYtFCGTIPASKHPRD; phosphoELM; RegPhos
T1165YTFCGtIEYCAPASKHPRD; phosphoELM; RegPhos
T1161GKLFYtFCGTIRegPhos
S1273VNKPEsGVLSAPhosphoSitePlus; HPRD; phosphoELM
S1280VLSAAsLEMGNPhosphoSitePlus; HPRD; phosphoELM
Y999EYSQKySTMSPPkinasePhosphoSitePlus
S582GVSGPsGSDLWPhosphoSitePlus
S956PGSTHsTAAELHPRD

Dephosphorylation site
PASK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000384016Q1233*COSMICOvarian Cancer21720365
ENSP00000234040R224CCOSMICOvarian Cancer21720365
ENSP00000351475V1272LBIOMARTBreast Cancer21930507, 21930502
ENSP00000351475S49CBIOMARTBreast Cancer21930507, 21930502
ENSP00000234040R298KCOSMICOvarian Cancer21720365
ENSP00000384016T1161NCOSMICOvarian Cancer21720365
ENSP00000234040R451LDing2008, COSMICLung Cancer18948947
ENSP00000384016E11KCOSMICMelanoma
ENSP00000384016R224CCOSMICOvarian Cancer21720365
ENSP00000384016E11KGreenman2007Skin Cancer17344846, 18428421
ENSP00000234040Q1233*COSMICOvarian Cancer21720365
ENSP00000384016R298KCOSMICOvarian Cancer21720365
ENSP00000234040V1265LBIOMARTBreast Cancer21930507, 21930502
ENSP00000384016S49CBIOMARTBreast Cancer21930507, 21930502
ENSP00000384016R451LDing2008, COSMICLung Cancer18948947
ENSP00000384016V1265LBIOMARTBreast Cancer21930507, 21930502
ENSP00000234040E11KGreenman2007Skin Cancer17344846, 18428421
ENSP00000234040S49CBIOMARTBreast Cancer21930507, 21930502
ENSP00000234040T1161NCOSMICOvarian Cancer21720365
ENSP00000234040E11KCOSMICMelanoma

Differential expressed protein
PASK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PASK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPASK_HUMANkinase -> substrateRegPhos
PASK_HUMANPASK_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
PASK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004871signal transducer activityIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0043576regulation of respiratory gaseous exchangeIEAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:2000505regulation of energy homeostasisIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0070092regulation of glucagon secretionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0035091phosphatidylinositol bindingIDAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0045727positive regulation of translationTASbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0045719negative regulation of glycogen biosynthetic proceIDAbiological_process