| UniProt/SwissProt ID: | OX1R_HUMAN |
| Description: | hypocretin (orexin) receptor 1 [Source:HGNC Symbol;Acc:4848] |
| Location: | chr1 p35.2 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y358 | ANPIIyNFLSG | TM; 7tm_1 | PhosphoSitePlus |
| Y124 | CKVIPyLQAVS | TM; 7tm_1 | PhosphoSitePlus |
| Y83 | RTVTNyFIVNL | TM; Form_Nir_trans; 7tm_1 | PhosphoSitePlus |
| Y27 | PVPPDyEDEFL | PhosphoSitePlus; HPRD; phosphoELM | |
| S138 | AVLTLsFIALD | TM; 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| OX1R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000384387 | V106L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000362810 | V106L | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| OX1R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| OX1R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| OREX_HUMAN | OX1R_HUMAN | ligand -> receptor | HPMR |
| IP3KA_HUMAN | OX1R_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016499 | orexin receptor activity | IEA | molecular_function |
| GO:0007218 | neuropeptide signaling pathway | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0007631 | feeding behavior | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0017046 | peptide hormone binding | IEA | molecular_function |