Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NSUN2_HUMAN
Description:NOP2/Sun RNA methyltransferase family, member 2 [Source:HGNC Symbol;Acc:25994]
Location:chr5 p15.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S244VNHDAsSIPRLFtsJPhosphoSitePlus
S475KLESPsFTGTGPhosphoSitePlus
Y83LRITGyKSHAKPhosphoSitePlus
S751AEEANsPDVTAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T755NSPDVtAGCDPHPRD; SysPTM
S139KILRKsPHLEKPhosphoSitePlus
T477ESPSFtGTGDTPhosphoSitePlus
T621NSRIItVSMEDPhosphoSitePlus
S456ESTQLsPADLTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T77EPLPAtLRITGPhosphoSitePlus
S233AKRLSsPCIMVFtsJPhosphoSitePlus
Y51KLFEHyYQELKPhosphoSitePlus; HPRD
T453ETREStQLSPAPhosphoSitePlus; HPRD
S623RIITVsMEDVKPhosphoSitePlus
Y646LSSETySQAKDPhosphoSitePlus
S564QLYMVsKELRNPhosphoSitePlus
T461SPADLtEGKPTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y561KKRQLyMVSKEPhosphoSitePlus
Y609AQEGIyTLYPFPhosphoSitePlus
S85ITGYKsHAKEIPhosphoSitePlus
S245NHDASsIPRLQFtsJPhosphoSitePlus
S139KILRKsPHLEKAURKBHPRD
T583MKVINtGIKVWPhosphoSitePlus; HPRD
S593WCRNNsGEEFDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T81ATLRItGYKSHPhosphoSitePlus
S473PSKLEsPSFTGPhosphoSitePlus; HPRD; SysPTM
S139KILRKsPHLEKAurB(STK12RegPhos
T449GKSAEtRESTQPhosphoSitePlus; HPRD
S743AGEPNsPDAEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S452AETREsTQLSPPhosphoSitePlus
S724NESAAsTGQPDHPRD; RegPhos

Dephosphorylation site
NSUN2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264670L699FCOSMICOvarian Cancer21720365
ENSP00000264670Y537CCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000264670Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3518646787
ENSP00000264670Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.2518646787
ENSP00000264670Gastric CancerMetastasiscell lineDown0.6817022644
ENSP00000264670Gastric CancerMetastasiscell lineDown0.6817022644
ENSP00000264670Breast CancerNormal vs. CancertissueUp0.520739354

Hyperphosphorylation site
NSUN2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANNSUN2_HUMANkinase -> substrateRegPhos
AURKB_HUMANNSUN2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
NSUN2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0016428tRNA (cytosine-5-)-methyltransferase activityIEAmolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0030488tRNA methylationIDAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0005819spindleIEAcellular_component
GO:0007067mitosisIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0000049tRNA bindingIEAmolecular_function


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