Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NOLC1_HUMAN
Description:nucleolar and coiled-body phosphoprotein 1 [Source:HGNC Symbol;Acc:15608]
Location:chr10 q24.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S90SDSEDsSEEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y289NKPGPySSVPPPhosphoSitePlus
T395KPAVTtKSPAVHPRD
S698SIKFDsE____PhosphoSitePlus
T38KFAKAtGATQQPhosphoSitePlus
S303PPPKKsLGTQPPhosphoSitePlus; HPRD
S521SSNSSsSDDSSHPRD
S55LLDIYsFWLKSPhosphoSitePlus
S230SSSDDsEEEKAPhosphoSitePlus; HPRD
S365ESSSDsSDSDSHPRD
S686SYRGGsISVQVSRP40_CPhosphoSitePlus
S623EKRASsPFRRVPKA_groupphosphoELM; RegPhos
S686SYRGGsISVQVHPRD
S622GEKRAsSPFRRPRKACAHPRD
Y682KKRGSyRGGSISRP40_CPhosphoSitePlus
T383SKPAGtTKNSSPhosphoSitePlus
S265PTRKSsSSEDSPhosphoSitePlus; HPRD
S643RVADNsFDAKRSRP40_CPhosphoSitePlus
T607KIKLQtPNTFPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S681KKKRGsYRGGSHPRD
S175DSDSSsEDEPPHPRD
S688RGGSIsVQVNSHPRD; RegPhos
S623EKRASsPFRRVPRKACAHPRD
S370SSDSDsSEDDEHPRD
T438SEEEKtKKMVAPhosphoSitePlus
S470GSRDSsSDSDSPhosphoSitePlus
S290KPGPYsSVPPPPhosphoSitePlus
S622GEKRAsSPFRRPKACaRegPhos
S271SSEDSsSDEEEPhosphoSitePlus; HPRD
S366SSSDSsDSDSSPhosphoSitePlus; HPRD
S218KAASSsSSSSSPhosphoSitePlus
S272SEDSSsDEEEEPhosphoSitePlus; HPRD
S174SDSDSsSEDEPHPRD
S681KKKRGsYRGGSSRP40_CPhosphoSitePlus
S219AASSSsSSSSSPhosphoSitePlus
S363AAESSsDSSDSHPRD
S84KKKASsSDSEDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T238EKAAAtPKKTVPhosphoSitePlus
S578AAVVVsKSGSLPhosphoSitePlus; HPRD
S296SVPPPsAPPPKPhosphoSitePlus
S520ESSNSsSSDDSHPRD
S222SSSSSsSSSSSPhosphoSitePlus
S623EKRASsPFRRVRegPhos
S693SVQVNsIKFDSSRP40_CPhosphoSitePlus
S688RGGSIsVQVNSSRP40_CPhosphoSitePlus
S87ASSSDsEDSSEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S563KAAKNsEEEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S526SSDDSsEEEEEHPRD
T384KPAGTtKNSSNPhosphoSitePlus
S622GEKRAsSPFRRPhosphoSitePlus; HPRD
S525SSSDDsSEEEEHPRD
S220ASSSSsSSSSSPhosphoSitePlus
S698SIKFDHPRD; phosphoELM
S264TPTRKsSSSEDPhosphoSitePlus; HPRD
T188QKPKItPVTVKPhosphoSitePlus; HPRD
S519AESSNsSSSDDHPRD
S266TRKSSsSEDSSHPRD
S698SIKFDsERegPhos
S397AVTTKsPAVKPPhosphoSitePlus; HPRD; RegPhos
T191KITPVtVKAQTPhosphoSitePlus
S378DDEAPsKPAGTPhosphoSitePlus
T610LQTPNtFPKRKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T41KATGAtQQDANPhosphoSitePlus
S522SNSSSsDDSSEHPRD
S291PGPYSsVPPPSPhosphoSitePlus
S173DSDSDsSSEDEPhosphoSitePlus; HPRD
S580VVVSKsGSLKKPhosphoSitePlus; HPRD
S504GGAAPsKPASAPhosphoSitePlus; HPRD
S623EKRASsPFRRVPKACaRegPhos
T597AKEAEtPQAKKPhosphoSitePlus; HPRD
S508PSKPAsAKKGKPhosphoSitePlus; HPRD; RegPhos
S216NGKAAsSSSSSPhosphoSitePlus
S270SSSEDsSSDEEPhosphoSitePlus; HPRD
S582VSKSGsLKKRKPhosphoSitePlus; HPRD
S516KGKAEsSNSSSHPRD
S91DSEDSsEEEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S223SSSSSsSSSSDPhosphoSitePlus
S643RVADNsFDAKRHPRD; phosphoELM; RegPhos
S517GKAESsNSSSSHPRD
S332DESDSsSEEEKHPRD
S333ESDSSsEEEKKPhosphoSitePlus; HPRD
S85KKASSsDSEDSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S83AKKKAsSSDSEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T261AATTPtRKSSSHPRD
T675FRHEKtKKKRGSRP40_CPhosphoSitePlus
S623EKRASsPFRRVSRP40_CPhosphoSitePlus
S669FTKGKsFRHEKSRP40_CPhosphoSitePlus
S267RKSSSsEDSSSHPRD
S217GKAASsSSSSSPhosphoSitePlus
S362KAAESsSDSSDPhosphoSitePlus; HPRD
S538LKGKGsPRPQAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S221SSSSSsSSSSSPhosphoSitePlus
S469QGSRDsSSDSDHPRD

Dephosphorylation site
NOLC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359024R262WCOSMICOvarian Cancer21720365
ENSP00000359024P116SBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000359024K162NCOSMICHead and Neck Cancer21798893
ENSP00000359024R262WTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000359024Hepatocellular CarcinomaNormal vs. Cancercell lineUp5.618646787
ENSP00000359024Ovarian CancerMetastasiscell lineUp3.317892554

Hyperphosphorylation site
NOLC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANNOLC1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANNOLC1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
NOLC1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006364rRNA processingTASbiological_process
GO:0007067mitosisTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0007000nucleolus organizationIEAbiological_process
GO:0005654nucleoplasmIEAcellular_component
GO:0007049cell cycleTASbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0015030Cajal bodyIEAcellular_component
GO:0005525GTP bindingIEAmolecular_function