Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NBN_HUMAN
Description:nibrin [Source:HGNC Symbol;Acc:7652]
Location:chr8 q21.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S341TTPGPsLSQGVPhosphoSitePlus; HPRD
Y429MRIPNyQLSPTPhosphoSitePlus; HPRD; SysPTM
S442PSINKsKDRASPhosphoSitePlus; HPRD
T434YQLSPtKLPSIPhosphoSitePlus; HPRD; phosphoELM
T60TNLSQtDEIPVFHAPhosphoSitePlus
S615ESSKIsQENEIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S278TGITNsQTLIPATMHPRD; phosphoELM; RegPhos
T497QTQPAtPSLWKPhosphoSitePlus; HPRD
S278TGITNsQTLIPPhosphoSitePlus
T485SARIEtSCSLLHPRD
S604TNDTFsDEAVPPhosphoSitePlus; HPRD
S58SVTNLsQTDEIHPRD
S611EAVPEsSKISQPhosphoSitePlus
S343PGPSLsQGVSVATMHPRD; phosphoELM; RegPhos
T516NEPVDtNSDNNPhosphoSitePlus
T493SLLEQtQPATPHPRD
S612AVPESsKISQEPhosphoSitePlus
S397KFRMLsQDAPTATMHPRD; phosphoELM; RegPhos; SysPTM
S488IETSCsLLEQTPhosphoSitePlus; HPRD
T60TNLSQtDEIPVHPRD
S58SVTNLsQTDEIFHAPhosphoSitePlus
Y16AGGEPyRLLTGPhosphoSitePlus
S499QPATPsLWKNKHPRD
T337GLKTTtPGPSLPhosphoSitePlus; HPRD
S706HIIGGsDLIAHNbs1_CPhosphoSitePlus
S292KKWIQsIMDMLPhosphoSitePlus
S438PTKLPsINKSKPhosphoSitePlus; HPRD
S347LSQGVsVDEKLPhosphoSitePlus
Y693FKKVTyPGAGKNbs1_CPhosphoSitePlus
T335STGLKtTTPGPPhosphoSitePlus
T602IETNDtFSDEAHPRD
T402SQDAPtVKESCPhosphoSitePlus; HPRD
S509KEQHLsENEPVPhosphoSitePlus
S195PPQIEsFYPPLPhosphoSitePlus
S661LTEFRsLVIKNHPRD
Y197QIESFyPPLDEPhosphoSitePlus
S343PGPSLsQGVSVPhosphoSitePlus; phosphoELM
T336TGLKTtTPGPSHPRD
S397KFRMLsQDAPTPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S432PNYQLsPTKLPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM

Dephosphorylation site
NBN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265433D95NHPIacute lymphocytic leukemia11325820 16702373
ENSP00000265433L150FHPIBreast Cancer14684699 16474176
ENSP00000265433Y679HCOSMICRenal Cancer21248752
ENSP00000265433R17TCOSMICHead and Neck Cancer21798893
ENSP00000265433T485MCOSMICHead and Neck Cancer21798893
ENSP00000265433I171VHPIacute lymphocytic leukemia11325820 15338273 22131123 21436738 19523210 19813148 18280732 18606567 19452044 18049891 17894553 17899368 16810201 17695489
ENSP00000265433E512GCOSMICLung Cancer20668451
ENSP00000265433L377FCOSMICHead and Neck Cancer21798893
ENSP00000265433I171VOMIMLeukemia11325820
ENSP00000265433P748SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000265433S93LHPIacute lymphocytic leukemia11325820
ENSP00000265433N731fs*20COSMICRenal Cancer20054297

Differential expressed protein
NBN_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S343TTPGPSLsQGVSVDERIDDLE syndrome17940005PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANNBN_HUMANkinase -> substrateRegPhos
ATM_HUMANNBN_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03440Homologous recombination

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0042405nuclear inclusion bodyIDAcellular_component
GO:0007126meiosisIEAbiological_process
GO:0005657replication forkIEAcellular_component
GO:0031954positive regulation of protein autophosphorylationIDAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0050885neuromuscular process controlling balanceIEAbiological_process
GO:0000784nuclear chromosome, telomeric regionIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0003684damaged DNA bindingIEAmolecular_function
GO:0000724double-strand break repair via homologous recombinTASbiological_process
GO:0030330DNA damage response, signal transduction by p53 clTASbiological_process
GO:0033674positive regulation of kinase activityIDAbiological_process
GO:0000723telomere maintenanceIMPbiological_process
GO:0030870Mre11 complexIDAcellular_component
GO:0007050cell cycle arrestTASbiological_process
GO:0031576G2/M transition checkpointIEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0001832blastocyst growthIEAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0032508DNA duplex unwindingIMPbiological_process
GO:0006281DNA repairTASbiological_process
GO:0045190isotype switchingIEAbiological_process
GO:0000077DNA damage checkpointIDAbiological_process
GO:0006302double-strand break repairIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0007095mitotic cell cycle G2/M transition DNA damage checIDAbiological_process
GO:0030174regulation of DNA-dependent DNA replication initiaTASbiological_process
GO:0004003ATP-dependent DNA helicase activityIMPmolecular_function
GO:0031575mitotic cell cycle G1/S transition checkpointIDAbiological_process
GO:0047485protein N-terminus bindingIPImolecular_function


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