| UniProt/SwissProt ID: | MTG16_HUMAN |
| Description: | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 [Source:HGNC Symbol;Acc:1537] |
| Location: | chr16 q24.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S439 | WARRYsDAEDT | NHR2 | PhosphoSitePlus |
| S459 | RPRSSsAGPEG | PhosphoSitePlus; HPRD | |
| S36 | SGLLAsAGCSA | PhosphoSitePlus | |
| S328 | PAQRYsPSNGP | HPRD | |
| S65 | SAMPDsPAEVK | PhosphoSitePlus | |
| S457 | AARPRsSSAGP | PhosphoSitePlus | |
| T337 | GPPQPtPPPHY | PhosphoSitePlus | |
| S629 | GAASPsEAGSA | PhosphoSitePlus | |
| S641 | PSRPGsPSPPG | PhosphoSitePlus | |
| T521 | AHELItTERAK | PhosphoSitePlus | |
| S458 | ARPRSsSAGPE | PhosphoSitePlus | |
| S373 | RPRSSsAGPEG | HPRD | |
| Y327 | NPAQRySPSNG | PhosphoSitePlus | |
| S242 | PAQRYsPSNGP | HPRD | |
| Dephosphorylation site |
| MTG16_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000268679 | E518K | HPI | Colorectal Cancer | 16959974 | ENSP00000268679 | E554K | COSMIC | Ovarian Cancer | 20668451 | ENSP00000268679 | R306H | HPI | Colorectal Cancer | 16959974 | ENSP00000268679 | R306H | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000268679 | A534V | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000268679 | E518K | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000268679 | A534V | HPI | Colorectal Cancer | 16959974 | ENSP00000268679 | D297fs*25 | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| MTG16_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MTG16_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RET_HUMAN | MTG16_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | MTG16_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MTG16_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005730 | nucleolus | IEA | cellular_component |
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0005654 | nucleoplasm | IEA | cellular_component |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0030851 | granulocyte differentiation | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0008283 | cell proliferation | TAS | biological_process |