Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MST4_HUMAN
Description:Serine/threonine-protein kinase MST4 [Source:UniProtKB/Swiss-Prot;Acc:Q9P289]
Location:chrX q26.2
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y89KYYGSyLKGSKPkinasePhosphoSitePlus
T178QIKRNtFVGTPPkinasePhosphoSitePlus
T178QIKRNtFVGTPHPRD
Y101WIIMEyLGGGSPkinasePhosphoSitePlus
T328EWSFTtVRKKPPhosphoSitePlus
S309SDSEGsDSESTPhosphoSitePlus; HPRD; phosphoELM
T172GQLTDtQIKRNHPRD
T182NTFVGtPFWMAPkinasePhosphoSitePlus
T170VAGQLtDTQIKPkinasePhosphoSitePlus
S325THPEWsFTTVRPhosphoSitePlus
T172GQLTDtQIKRNPkinasePhosphoSitePlus
T320SRENNtHPEWSPhosphoSitePlus
S4VAVQHPRD
S304HSDDEsDSEGSPhosphoSitePlus; HPRD; phosphoELM
S260LNKDPsFRPTAPkinasePhosphoSitePlus
S4__MAHsPVAVQPhosphoSitePlus
T327PEWSFtTVRKKPhosphoSitePlus; HPRD
S306DDESDsEGSDSPhosphoSitePlus; HPRD; phosphoELM
S300KAEGHsDDESDPhosphoSitePlus; HPRD; phosphoELM
T264PSFRPtAKELLPkinasePhosphoSitePlus
Y86YVTKYyGSYLKPkinasePhosphoSitePlus

Dephosphorylation site
MST4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377867G36WGreenman2007, HPIGastric Cancer17344846
ENSP00000377867R262LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
MST4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MST4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MST4_HUMANLZTS1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MST4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityIDAmolecular_function
GO:0042981regulation of apoptotic processIDAbiological_process
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0006915apoptotic processTASbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0000139Golgi membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0042802identical protein bindingIPImolecular_function


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