| UniProt/SwissProt ID: | MPZL1_HUMAN |
| Description: | myelin protein zero-like 1 [Source:HGNC Symbol;Acc:7226] |
| Location: | chr1 q24.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S208 | CSTSEsLSPVK | Rax2 | PhosphoSitePlus |
| S210 | TSESLsPVKQA | Rax2 | PhosphoSitePlus; SysPTM |
| S22 | RRWLWsVLAAA | PhosphoSitePlus | |
| Y241 | QGPVIyAQLDH | Myelin-PO_C | PhosphoSitePlus |
| T205 | YTGCStSESLS | HPRD; phosphoELM | |
| S210 | TSESLsPVKQA | HPRD; phosphoELM; RegPhos; SysPTM | |
| Y200 | NSKRDyTGCST | phosphoELM; RegPhos | |
| S16 | IAAPDsRRWLW | PhosphoSitePlus; HPRD | |
| S258 | DKINKsESVVY | HPRD; phosphoELM | |
| S206 | TGCSTsESLSP | HPRD; phosphoELM | |
| Y241 | QGPVIyAQLDH | SRC | HPRD; phosphoELM; RegPhos |
| S204 | DYTGCsTSESL | HPRD; phosphoELM | |
| Y263 | SESVVyADIR | SRC | HPRD; phosphoELM; SysPTM |
| Y263 | SESVVyADIR | phosphoELM; SysPTM | |
| T205 | YTGCStSESLS | Rax2 | PhosphoSitePlus |
| Y263 | SESVVyADIRK | Src | RegPhos; SysPTM |
| S208 | CSTSEsLSPVK | HPRD; phosphoELM | |
| S260 | INKSEsVVYAD | Myelin-PO_C | PhosphoSitePlus |
| S247 | AQLDHsGGHHS | Myelin-PO_C | PhosphoSitePlus |
| Y241 | QGPVIyAQLDH | phosphoELM; RegPhos | |
| Y263 | SESVVyADIRK | RegPhos; SysPTM | |
| Y200 | NSKRDyTGCST | Rax2; Adeno_E3_CR2 | PhosphoSitePlus |
| S252 | SGGHHsDKINK | Myelin-PO_C | PhosphoSitePlus |
| Y263 | SESVVyADIRK | SRC | RegPhos; SysPTM |
| Y263 | SESVVyADIRK | Myelin-PO_C | PhosphoSitePlus; SysPTM |
| S221 | PRKSPsDTEGL | PhosphoSitePlus; HPRD; phosphoELM | |
| S260 | INKSEsVVYAD | HPRD; phosphoELM | |
| S258 | DKINKsESVVY | Myelin-PO_C | PhosphoSitePlus |
| S206 | TGCSTsESLSP | Rax2 | PhosphoSitePlus |
| T32 | ALGLLtAGVSA | PhosphoSitePlus | |
| T223 | KSPSDtEGLVK | HPRD; SysPTM | |
| S232 | VKSLPsGSHQG | Myelin-PO_C | PhosphoSitePlus |
| S234 | SLPSGsHQGPV | Myelin-PO_C | PhosphoSitePlus |
| S229 | EGLVKsLPSGS | Myelin-PO_C | PhosphoSitePlus |
| Y241 | QGPVIyAQLDH | Src | RegPhos |
| S219 | QAPRKsPSDTE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y263 | NKSESVVyADIRKN | PTPN11 | HPRD |
| Y241 | SHQGPVIyAQLDHSG | PTPN11 | HPRD |
| Y200 | RKNSKRDyTGCSTSE | PTPN11 | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000352513 | G68R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000375968 | G68R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000352513 | A188G | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| MPZL1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MPZL1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SRC_HUMAN | MPZL1_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | MPZL1_HUMAN | kinase -> substrate | RegPhos |
| PTN11_HUMAN | MPZL1_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04514 | Cell adhesion molecules (CAMs) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0005198 | structural molecule activity | TAS | molecular_function |