Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MERTK_HUMAN
Description:c-mer proto-oncogene tyrosine kinase [Source:HGNC Symbol;Acc:7027]
Location:chr2 q13
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y754YSGDYyRQGRIMERTKHPRD
S543FTEEDsELVVNPhosphoSitePlus
Y753IYSGDyYRQGRPkinase_TyrPhosphoSitePlus
S613QEDGTsLKVAVPkinase_TyrPhosphoSitePlus
T458HNATCtVRIAAfn3PhosphoSitePlus
Y754YSGDYyRQGRIautocatalysis RegPhos
Y749LSKKIySGDYYPkinase_TyrPhosphoSitePlus
Y753IYSGDyYRQGRMerphosphoELM; RegPhos
T458HNATCtVRIAAHPRD
T699HIPLQtLLKFMPkinase_TyrPhosphoSitePlus
Y754YSGDYyRQGRIMERRegPhos
Y754YSGDYyRQGRIMerphosphoELM; RegPhos
Y753IYSGDyYRQGRMERRegPhos
S935ILNGGsEEWEDPhosphoSitePlus
Y549ELVVNyIAKKSPhosphoSitePlus
S750SKKIYsGDYYRPkinase_TyrPhosphoSitePlus
Y929PHEGRyILNGGPhosphoSitePlus
Y749LSKKIySGDYYMerphosphoELM; RegPhos
Y749LSKKIySGDYYMERTKHPRD
Y749LSKKIySGDYYMERRegPhos
Y753IYSGDyYRQGRMERTKHPRD
S645CMKDFsHPNVIPkinase_TyrPhosphoSitePlus
Y754YSGDYyRQGRIPkinase_TyrPhosphoSitePlus

Dephosphorylation site
MERTK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000295408P672SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000295408M790VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000295408S159FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000295408A708SGreenman2007, HPIHead and Neck Cancer17344846, 18428421
ENSP00000295408A446GGreenman2007, HPIRenal Cancer17344846, 18428421
ENSP00000295408I431FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000295408G594RBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
MERTK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MERTK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GAS6_HUMANMERTK_HUMANligand -> receptorHPMR
MERTK_HUMANMERTK_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
MERTK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050900leukocyte migrationTASbiological_process
GO:0060068vagina developmentIEAbiological_process
GO:0006909phagocytosisIEAbiological_process
GO:0001750photoreceptor outer segmentIEAcellular_component
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0001779natural killer cell differentiationIEAbiological_process
GO:0060041retina development in camera-type eyeIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0007267cell-cell signalingTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0016028rhabdomereIDAcellular_component
GO:0007283spermatogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030168platelet activationIEAbiological_process
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0043277apoptotic cell clearanceIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0032940secretion by cellIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0051250negative regulation of lymphocyte activationIEAbiological_process
GO:0006909phagocytosisIMPbiological_process
GO:0034446substrate adhesion-dependent cell spreadingIEAbiological_process
GO:0050766positive regulation of phagocytosisIDAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005886plasma membraneTAScellular_component
GO:0006468protein phosphorylationIEAbiological_process


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