Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MBNL1_HUMAN
Description:muscleblind-like splicing regulator 1 [Source:HGNC Symbol;Acc:6923]
Location:chr3 q25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T270TAAAMtQSAVKPhosphoSitePlus
S272AAMTQsAVKSLPhosphoSitePlus
Y188EVCREyQRGNCzf-CCCHPhosphoSitePlus
Y224TVCMDyIKGRCzf-CCCHPhosphoSitePlus
S208AHPADsTMIDTPhosphoSitePlus
T265AQAAAtAAAMTPhosphoSitePlus

Dephosphorylation site
MBNL1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282486S28*TCGAOvarian Cancer21720365, 18772890
ENSP00000418108S28*TCGAOvarian Cancer21720365, 18772890
ENSP00000282486S129*COSMICHead and Neck Cancer21798893
ENSP00000282486S28*COSMICOvarian Cancer21720365
ENSP00000319429P328LBIOMARTNeoplasms by Histologic Type21930507, 21930502

Differential expressed protein
MBNL1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MBNL1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ARAF_HUMANMBNL1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MBNL1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0030326embryonic limb morphogenesisISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0000381regulation of alternative mRNA splicing, via splicIEAbiological_process
GO:0001701in utero embryonic developmentISSbiological_process
GO:0006376mRNA splice site selectionIEAbiological_process
GO:0003725double-stranded RNA bindingIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0008380RNA splicingIDAbiological_process
GO:0007519skeletal muscle tissue developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043484regulation of RNA splicingIDAbiological_process
GO:0007399nervous system developmentISSbiological_process
GO:0000380alternative mRNA splicing, via spliceosomeIEAbiological_process
GO:0003723RNA bindingIDAmolecular_function
GO:0045445myoblast differentiationISSbiological_process
GO:0005634nucleusIEAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0010494cytoplasmic stress granuleIDAcellular_component


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