Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LRP2_HUMAN
Description:low density lipoprotein receptor-related protein 2 [Source:HGNC Symbol;Acc:6694]
Location:chr2 q31.1
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y580DSRFDyIETVTLdl_recept_bPhosphoSitePlus
S4636PTPTYsATEDTPhosphoSitePlus
Y586IETVTyDGIQRLdl_recept_bPhosphoSitePlus
S1638RQVIAsDLIIRLdl_recept_bPhosphoSitePlus
T4634RDPTPtYSATEPhosphoSitePlus
S3022DCGDYsDERGCLdl_recept_aPhosphoSitePlus
T898KIEHStFDGLDLdl_recept_bPhosphoSitePlus
T4451FHYRRtGSLLPPhosphoSitePlus
Y4635DPTPTySATEDPhosphoSitePlus
Y572ISKRVyWVDSRLdl_recept_bPhosphoSitePlus
S2704RCGASsFTCSNLdl_recept_aPhosphoSitePlus
S4627KPKPPsRRDPTPhosphoSitePlus
S4587LFKRKsKQTTNPhosphoSitePlus
S4181RKWLIsTDLDQLdl_recept_bPhosphoSitePlus
Y3021NDCGDySDERGLdl_recept_aPhosphoSitePlus
S4569ETNPTsPAADGHPRD
T1912GTSVKtLFTGNLdl_recept_bPhosphoSitePlus
Y3242VEKRLyWIDTQLdl_recept_bPhosphoSitePlus
Y3029ERGCLyQTCQQPhosphoSitePlus
S1030QCGLFsFPCKNLdl_recept_aPhosphoSitePlus
T4645DTFKDtANLVKPhosphoSitePlus
Y805WTDSHyKSISVLdl_recept_bPhosphoSitePlus
Y4028NTKGSyECVCAcEGFPhosphoSitePlus
T4638PTYSAtEDTFKPhosphoSitePlus
S4527ENPMYsARDSAPhosphoSitePlus
T3031GCLYQtCQQNQLdl_recept_aPhosphoSitePlus
T4478NGNGVtFRSGAPhosphoSitePlus
S897DKIEHsTFDGLLdl_recept_bPhosphoSitePlus
S4616ATPPPsPSLPAPhosphoSitePlus
Y4598FENPIyAQMENPhosphoSitePlus
T563WPAGVtLDMISLdl_recept_bPhosphoSitePlus
Y4526FENPMySARDSPhosphoSitePlus
T4641SATEDtFKDTAPhosphoSitePlus
S1902PAKIAsANMDGLdl_recept_bPhosphoSitePlus
S4653LVKEDsEV___PhosphoSitePlus

Dephosphorylation site
LRP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263816R4585XBIOMARTColorectal Cancer21930507, 21930502
ENSP00000263816R3399*COSMICIntestines Cancer16959974
ENSP00000263816Q1959KCOSMICOvarian Cancer21720365
ENSP00000263816S313CBIOMARTBreast Cancer21930507, 21930502
ENSP00000263816W3422*COSMICMelanoma21499247
ENSP00000263816C103RCOSMICRenal Cancer21248752
ENSP00000263816R4585*COSMICIntestines Cancer16959974
ENSP00000263816G901ACOSMICHead and Neck Cancer21798893
ENSP00000263816M4272VHPIColorectal Cancer16959974
ENSP00000263816E3395GCOSMICOvarian Cancer21720365
ENSP00000263816N3894KCOSMICOvarian Cancer21720365
ENSP00000263816G4404SCOSMICMelanoma21499247
ENSP00000263816R4319QCOSMICSkin Cancer21984974
ENSP00000263816R3043HCOSMICOvarian Cancer21720365
ENSP00000263816S1729LBIOMARTBreast Cancer21930507, 21930502
ENSP00000263816L2297SCOSMICOvarian Cancer21720365
ENSP00000263816A935VCOSMICOvarian Cancer21720365
ENSP00000263816G2265VCOSMICHead and Neck Cancer21798893
ENSP00000263816V444MCOSMICOvarian Cancer21720365
ENSP00000263816V3050ICOSMICCentral Nervous System Neoplasms18772396
ENSP00000263816W2475*COSMICMelanoma21499247
ENSP00000263816A3412DCOSMICOvarian Cancer21720365
ENSP00000263816N682ICOSMICOvarian Cancer21720365
ENSP00000263816S2395PCOSMICOvarian Cancer21720365
ENSP00000263816D815NCOSMICMelanoma21499247
ENSP00000263816W2523SCOSMICOvarian Cancer21720365
ENSP00000263816R2904QCOSMICSkin Cancer21984974
ENSP00000263816A1967ECOSMICOvarian Cancer21720365
ENSP00000263816V263ICOSMICOvarian Cancer21720365
ENSP00000263816S2042CCOSMICOvarian Cancer21720365
ENSP00000263816D1016NCOSMICCentral Nervous System Neoplasms18772396
ENSP00000263816W1731CBIOMARTBreast Cancer21930507, 21930502
ENSP00000263816G858RCOSMICPancreatic Cancer
ENSP00000263816D403NCOSMICHead and Neck Cancer21984974
ENSP00000263816R3399XBIOMARTColorectal Cancer21930507, 21930502
ENSP00000263816C4353RBIOMARTBreast Cancer21930507, 21930502
ENSP00000263816M4272VSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000263816C3519GCOSMICOvarian Cancer21720365
ENSP00000263816A1515VCOSMICHead and Neck Cancer21798893
ENSP00000263816A4571VCOSMICSkin Cancer21984974
ENSP00000263816R1085HCOSMICCentral Nervous System Neoplasms18772396
ENSP00000263816R3551HBIOMARTBreast Cancer21930507, 21930502
ENSP00000263816V2583MCOSMICCentral Nervous System Neoplasms18772396
ENSP00000263816R2243QCOSMICHead and Neck Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000263816Renal CancerNormal vs. CancertissueDown19164279

Hyperphosphorylation site
LRP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANGT_HUMANLRP2_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04340Hedgehog signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005905coated pitIEAcellular_component
GO:0006898receptor-mediated endocytosisIEAbiological_process
GO:0008202steroid metabolic processTASbiological_process
GO:0005768endosomeIEAcellular_component
GO:0006486protein glycosylationTASbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0006766vitamin metabolic processIEAbiological_process
GO:0006897endocytosisTASbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0016324apical plasma membraneISScellular_component
GO:0042359vitamin D metabolic processTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005764lysosomeTAScellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0030139endocytic vesicleIEAcellular_component
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0030900forebrain developmentIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0006629lipid metabolic processTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0031526brush border membraneIEAcellular_component
GO:0045177apical part of cellIEAcellular_component
GO:0005903brush borderIEAcellular_component