| UniProt/SwissProt ID: | LOX5_HUMAN |
| Description: | arachidonate 5-lipoxygenase [Source:HGNC Symbol;Acc:435] |
| Location: | chr10 q11.21 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S664 | PYYYLsPDRIP | Lipoxygenase | PhosphoSitePlus |
| S183 | FVLNYsKAMEN | Lipoxygenase | PhosphoSitePlus |
| S532 | PKSVKsREQLS | Lipoxygenase; DUF1250 | PhosphoSitePlus |
| T105 | CYRWItGDVEV | PLAT | PhosphoSitePlus |
| S272 | LERQLsLEQEV | PKA_group | phosphoELM; RegPhos |
| T87 | YLKYItLKTPH | PLAT | PhosphoSitePlus |
| S272 | LERQLsLEQEV | CaM-KII_alpha | phosphoELM |
| Y75 | IEKRKyWLNDD | PLAT | PhosphoSitePlus |
| S524 | RGRKSsGFPKS | Lipoxygenase; DUF1250 | PhosphoSitePlus |
| S524 | RGRKSsGFPKS | PKA_group | phosphoELM; RegPhos |
| S272 | LERQLsLEQEV | MAPKAPK2 | HPRD; phosphoELM; RegPhos |
| S272 | LERQLsLEQEV | Lipoxygenase | PhosphoSitePlus |
| S272 | LERQLsLEQEV | CaMK2a | RegPhos |
| Y182 | DFVLNySKAME | Lipoxygenase | PhosphoSitePlus |
| Dephosphorylation site |
| LOX5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363512 | T138R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363512 | R248C | COSMIC | Pancreatic Cancer | ENSP00000363512 | T138R | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| LOX5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LOX5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MAPK2_HUMAN | LOX5_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04726 | Serotonergic synapse |
| hsa00590 | Arachidonic acid metabolism |
| hsa01100 | Metabolic pathways |
| hsa05145 | Toxoplasmosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016165 | lipoxygenase activity | IEA | molecular_function |
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0031965 | nuclear membrane | IDA | cellular_component |
| GO:0005635 | nuclear envelope | IDA | cellular_component |
| GO:0019370 | leukotriene biosynthetic process | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0002540 | leukotriene production involved in inflammatory re | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006691 | leukotriene metabolic process | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0019370 | leukotriene biosynthetic process | IEA | biological_process |
| GO:0005641 | nuclear envelope lumen | IDA | cellular_component |
| GO:0005506 | iron ion binding | IDA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006691 | leukotriene metabolic process | TAS | biological_process |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |
| GO:0004051 | arachidonate 5-lipoxygenase activity | IDA | molecular_function |
| GO:0016702 | oxidoreductase activity, acting on single donors w | IEA | molecular_function |
| GO:0016363 | nuclear matrix | IDA | cellular_component |