| UniProt/SwissProt ID: | KREM1_HUMAN |
| Description: | kringle containing transmembrane protein 1 [Source:HGNC Symbol;Acc:17550] |
| Location: | chr22 q12.1 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T341 | VAEVItEQANL | PhosphoSitePlus | |
| T335 | PAVNQtVAEVI | PhosphoSitePlus | |
| Dephosphorylation site |
| KREM1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000385431 | R277H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000383189 | R279H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000331242 | E182K | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000331242 | A339S | COSMIC | Lung Cancer | 20668451 | ENSP00000331242 | V93L | COSMIC | Lung Cancer | ENSP00000331242 | R279H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000331242 | S421F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000385431 | *474G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000331242 | G217R | COSMIC | Ovarian Cancer | 20668451 |
| Differential expressed protein |
| KREM1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KREM1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DKK1_HUMAN | KREM1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KREM1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0060828 | regulation of canonical Wnt receptor signaling pat | NAS | biological_process |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007154 | cell communication | TAS | biological_process |