| UniProt/SwissProt ID: | KPCD3_HUMAN |
| Description: | protein kinase D3 [Source:HGNC Symbol;Acc:9408] |
| Location: | chr2 p22.2 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S252 | SKRIPsWSGRP | PhosphoSitePlus; HPRD; SysPTM | |
| S41 | LSARLsNGSFS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S44 | RLSNGsFSAPS | PhosphoSitePlus; HPRD; phosphoELM | |
| T389 | EEAVKtISPST | PhosphoSitePlus | |
| S395 | ISPSTsNNIPL | PhosphoSitePlus; HPRD | |
| S37 | PKTGLsARLSN | PhosphoSitePlus; HPRD | |
| S247 | VHQEPsKRIPS | HPRD | |
| S254 | RIPSWsGRPIW | PhosphoSitePlus | |
| S731 | IIGEKsFRRSV | HPRD; phosphoELM | |
| S216 | RLSNVsLPGPG | PhosphoSitePlus; HPRD; SysPTM | |
| S735 | KSFRRsVVGTP | Pkinase | PhosphoSitePlus; SysPTM |
| S30 | AASPCsSPKTG | PhosphoSitePlus; HPRD; phosphoELM | |
| S213 | RKRRLsNVSLP | PhosphoSitePlus; HPRD; SysPTM | |
| S6 | MSANNsPPSAQ | PhosphoSitePlus; SysPTM | |
| Y742 | VGTPAyLAPEV | Pkinase | PhosphoSitePlus |
| S223 | PGPGLsVPRPL | HPRD | |
| S237 | YVALPsEESHV | HPRD | |
| S2 | ____MsANNSP | PhosphoSitePlus | |
| S415 | TKRKSsTMVKE | PhosphoSitePlus | |
| Y867 | WEIHAyTHNLV | PhosphoSitePlus | |
| S13 | PSAQKsVLPTA | HPRD | |
| T739 | RSVVGtPAYLA | HPRD | |
| S391 | AVKTIsPSTSN | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S543 | ASVCTsPGQGK | PhosphoSitePlus; HPRD; SysPTM | |
| T542 | QASVCtSPGQG | HPRD | |
| S393 | KTISPsTSNNI | HPRD | |
| S539 | VTPQAsVCTSP | HPRD | |
| S31 | ASPCSsPKTGL | PhosphoSitePlus; HPRD; phosphoELM | |
| S364 | DTEEPsPPEDK | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S735 | KSFRRsVVGTP | HPRD; phosphoELM; SysPTM | |
| T535 | ALMPVtPQASV | PhosphoSitePlus; HPRD; SysPTM | |
| S731 | IIGEKsFRRSV | Pkinase | PhosphoSitePlus |
| S6 | PSAQ | HPRD; SysPTM | |
| Y852 | RIGERyITHES | PhosphoSitePlus | |
| S9 | NNSPPsAQKSV | HPRD | |
| S27 | VLPAAsPCSSP | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| KPCD3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000368356 | L687F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000234179 | V716M | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000234179 | V716M | Greenman2007, HPI | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000368356 | R211C | Ding2008 | Lung Cancer | 18948947 | ENSP00000234179 | E231D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000368356 | L812M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000368356 | R211C | BIOMART | Lung Cancer | 21930507, 21930502 | ENSP00000234179 | R211C | Ding2008 | Lung Cancer | 18948947 | ENSP00000368356 | E231D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000234179 | L687F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000368356 | V716M | Greenman2007, HPI | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000368356 | P236L | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000368356 | F307S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000234179 | P236L | Ding2008 | Lung Cancer | 18948947 | ENSP00000368356 | V716M | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 |
| Differential expressed protein |
| KPCD3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KPCD3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCD3_HUMAN | GSK3A_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KPCD3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0007205 | protein kinase C-activating G-protein coupled rece | TAS | biological_process |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0009103 | lipopolysaccharide biosynthetic process | IEA | biological_process |
| GO:0004697 | protein kinase C activity | IEA | molecular_function |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005543 | phospholipid binding | IEA | molecular_function |