Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KIF11_HUMAN
Description:kinesin family member 11 [Source:HGNC Symbol;Acc:6388]
Location:chr10 q23.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T925DIPTGtTPQRKMicrotub_bindPhosphoSitePlus
S931TPQRKsYLYPSMicrotub_bindPhosphoSitePlus; SysPTM
S323RILQDsLGGRTKinesinPhosphoSitePlus
T506NTVEEtTKDVSHPRD
T925DIPTGtTPQRKHPRD; phosphoELM
T923KLDIPtGTTPQHPRD; phosphoELM; SysPTM
S233MNAYSsRSHSVHPRD
S120MEGERsPNEEYKinesinPhosphoSitePlus
T663FKTSLtVADKIPhosphoSitePlus
S852LLEVVsQCCEAPhosphoSitePlus
S232LMNAYsSRSHSKinesinPhosphoSitePlus
T926IPTGTtPQRKSMicrotub_bindPhosphoSitePlus; SysPTM
T226RTTAAtLMNAYKinesinPhosphoSitePlus
Y480LVKEEyITSALPhosphoSitePlus
T223AAKRTtAATLMKinesinPhosphoSitePlus
T114TGKTFtMEGERKinesinPhosphoSitePlus
T926IPTGTtPQRKSCDC2(CDK1RegPhos; SysPTM
Y211NKDEVyQILEKKinesinPhosphoSitePlus
T458DLQNKtQELETPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y125SPNEEyTWEEDKinesinPhosphoSitePlus
T507TVEETtKDVSGPhosphoSitePlus; HPRD
T643MILSPtVVSILPhosphoSitePlus
S62LADKSsRKTYTHPRD; SysPTM
T294NQSLLtLGRVIKinesinPhosphoSitePlus
S1033NTLERsKVEETHPRD
T926IPTGTtPQRKSHPRD; SysPTM
T126PNEEYtWEEDPKinesinPhosphoSitePlus
Y231TLMNAySSRSHHPRD
Y934RKSYLyPSTLVMicrotub_bindPhosphoSitePlus
T464QELETtQKHLQPhosphoSitePlus
S240SHSVFsVTIHMKinesinPhosphoSitePlus
S858QCCEAsSSDITPhosphoSitePlus
S1033NTLERsKVEETMicrotub_bindPhosphoSitePlus
Y231TLMNAySSRSHKinesinPhosphoSitePlus
S401NGVYIsEENFRPhosphoSitePlus
S291GNINQsLLTLGKinesinPhosphoSitePlus
S931TPQRKsYLYPSHPRD; phosphoELM; RegPhos; SysPTM
T1029NRGINtLERSKMicrotub_bindPhosphoSitePlus
T926IPTGTtPQRKSCDK_groupphosphoELM; RegPhos; SysPTM
T926IPTGTtPQRKSCDC2RegPhos; SysPTM
S652ILKINsQLKHIPhosphoSitePlus
S232LMNAYsSRSHSHPRD
S233MNAYSsRSHSVKinesinPhosphoSitePlus
T463TQELEtTQKHLPhosphoSitePlus
Y932PQRKSyLYPSTMicrotub_bindPhosphoSitePlus
T923KLDIPtGTTPQMicrotub_bindPhosphoSitePlus; SysPTM
T1029NRGINtLERSKHPRD
Y399EKNGVyISEENPhosphoSitePlus
T926IPTGTtPQRKSCDK1HPRD; phosphoELM; SysPTM

Dephosphorylation site
KIF11_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000260731M638LCOSMICMelanoma21499247
ENSP00000260731A230VCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000260731Small cell lung carcinomaTreatment (none vs. isogenic Doxorubicin-resistant)cell lineUp4.418654985
ENSP00000260731Uterine CancerNormal vs. Cancercell lineUp1100015838902

Hyperphosphorylation site
KIF11_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANKIF11_HUMANkinase -> substrateRegPhos
CDK1_HUMANKIF11_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KIF11_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007067mitosisTASbiological_process
GO:0005819spindleIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0000922spindle poleIDAcellular_component
GO:0019901protein kinase bindingIPImolecular_function
GO:0005875microtubule associated complexIEAcellular_component
GO:0090307spindle assembly involved in mitosisIDAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0019886antigen processing and presentation of exogenous pTASbiological_process
GO:0008017microtubule bindingIEAmolecular_function
GO:0016585chromatin remodeling complexIDAcellular_component
GO:0007100mitotic centrosome separationIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0005871kinesin complexTAScellular_component
GO:0005874microtubuleIDAcellular_component
GO:0007051spindle organizationIMPbiological_process
GO:0007018microtubule-based movementTASbiological_process
GO:0003777microtubule motor activityIEAmolecular_function
GO:0005876spindle microtubuleIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0007052mitotic spindle organizationTASbiological_process


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