Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KDIS_HUMAN
Description:kinase D-interacting substrate, 220kDa [Source:HGNC Symbol;Acc:29508]
Location:chr2 p25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1411ISGRSsPHSTYPhosphoSitePlus
Y169NCSDKyGTTPLAnk_2PhosphoSitePlus
S1352NLSWQsQTRRTPhosphoSitePlus
T216VKGGYtQSVKEAnk_2PhosphoSitePlus
S1361RTPSLsSLNSQHPRD
Y1383KVQAEyRDAYRPhosphoSitePlus
S1359TRRTPsLSSLNPhosphoSitePlus; HPRD
Y307NKTALyWAVEKAnk_2PhosphoSitePlus
S1681LNRTPsTVTLNPhosphoSitePlus
S1163LISRPsVKTSLPhosphoSitePlus
S1309PARRAsHNELPPhosphoSitePlus
S1410TISGRsSPHSTPhosphoSitePlus
S203QEGANsMTALIAnk_2PhosphoSitePlus
S932TEDWFsDISPQKAP_NTPasePhosphoSitePlus
Y1674ACQKAyNLNRTPhosphoSitePlus
T1682NRTPStVTLNNPhosphoSitePlus
S1349RHSNLsWQSQTPhosphoSitePlus
Y1079IGGLAyPPLPLPhosphoSitePlus
T1679YNLNRtPSTVTPhosphoSitePlus
S1741RSQRSsYTRLSPhosphoSitePlus
Y1125PHSSYySGMTGPhosphoSitePlus
S1486EKSDQsGSKLLPhosphoSitePlus
S1709GIRETsQVILRPhosphoSitePlus
S885RVSQNsLGEMTKAP_NTPasePhosphoSitePlus
S1295FLSESsSGPAPPhosphoSitePlus
Y1742SQRSSyTRLSKPhosphoSitePlus
S882ADRRVsQNSLGKAP_NTPasePhosphoSitePlus
S1731NENLKsMTHKRPhosphoSitePlus
S1555ERVPKsPEHSAPhosphoSitePlus; HPRD
S1365LSSLNsQDSSIPhosphoSitePlus; HPRD
S1633IPHSLsGLQDPPhosphoSitePlus
Y1572IKAKEyLSDALPhosphoSitePlus
S1329YTLNFsFEELNPhosphoSitePlus
T1684TPSTVtLNNNSPhosphoSitePlus
Y1387EYRDAyREYIAPhosphoSitePlus
S1607EVADDsQLEKAPhosphoSitePlus
Y1146FAPYLyTPRYYPhosphoSitePlus
S918ITRQMsFDLTKKAP_NTPasePhosphoSitePlus
S918ITRQMsFDLTKPRKD1HPRD
S1737MTHKRsQRSSYPhosphoSitePlus
T1528EDESGtEESDNHPRD
Y215AVKGGyTQSVKAnk_2PhosphoSitePlus
S1526SDEDEsGTEESPhosphoSitePlus; HPRD
S1488SDQSGsKLLPGPhosphoSitePlus
S1521YQKLPsDEDESPhosphoSitePlus; HPRD
T927TKLLVtEDWFSKAP_NTPasePhosphoSitePlus
S1373SSIEIsKLTDKPhosphoSitePlus
T1357SQTRRtPSLSSPhosphoSitePlus
S1716VILRPsSSPNPPhosphoSitePlus; HPRD
S244ALMIAsKEGHTAnkPhosphoSitePlus
S1362TPSLSsLNSQDPhosphoSitePlus; HPRD
S1294RFLSEsSSGPAPhosphoSitePlus
S1559KSPEHsAEPIRPhosphoSitePlus; HPRD
Y1390DAYREyIAQMSPhosphoSitePlus
S1621ELEDDsHSGKRPhosphoSitePlus; HPRD
S1718LRPSSsPNPTTPhosphoSitePlus; HPRD

Dephosphorylation site
KDIS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000418974S244LBIOMARTBreast Cancer21930507, 21930502
ENSP00000256707I538LCOSMICHead and Neck Cancer21984974
ENSP00000414923S202LBIOMARTBreast Cancer21930507, 21930502
ENSP00000256707S244LBIOMARTBreast Cancer21930507, 21930502
ENSP00000411849S244LBIOMARTBreast Cancer21930507, 21930502
ENSP00000319947S245LBIOMARTBreast Cancer21930507, 21930502
ENSP00000256707T455ICOSMICSkin Cancer21984974

Differential expressed protein
KDIS_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KDIS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD1_HUMANKDIS_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016021integral to membraneIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0000186activation of MAPKK activityTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0048813dendrite morphogenesisIEAbiological_process


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