Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KCNH2_HUMAN
Description:potassium voltage-gated channel, subfamily H (eag-related), member 2 [Source:HGNC Symbol;Acc:6251]
Location:chr7 q36.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1009SRGRQyQELPRPhosphoSitePlus
S320LLNSTsDSDLVPhosphoSitePlus
S1137PTRRLsLPGQLPKACaRegPhos
S890RKRKLsFRRRTPhosphoSitePlus
S1137PTRRLsLPGQLPhosphoSitePlus; phosphoELM
S283SVRRAsSADDIPKACaRegPhos
Y611SIKDKyVTALYIon_transPhosphoSitePlus
Y475NFRTTyVNANEIon_transPhosphoSitePlus
S283SVRRAsSADDIPhosphoSitePlus
S283SVRRAsSADDIPRKACAHPRD
S322NSTSDsDLVRYPhosphoSitePlus
S1137PTRRLsLPGQLPRKACAHPRD
S1029NIPLSsPGRRPPhosphoSitePlus
T895SFRRRtDKDTEPhosphoSitePlus
S283SVRRAsSADDIPKA_groupphosphoELM; RegPhos
S882LEGGFsRQRKRPhosphoSitePlus
S797PTRRLsLPGQLPRKACAHPRD
S1137PTRRLsLPGQLPKA_groupphosphoELM; RegPhos

Dephosphorylation site
KCNH2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262186E435KCOSMICSkin Cancer21984974
ENSP00000262186P1075SCOSMICSkin Cancer21984974
ENSP00000262186D383NCOSMICOvarian Cancer21720365
ENSP00000262186L468FCOSMICMelanoma20016485

Differential expressed protein
KCNH2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S890RQRKRKLsFRRRTDKventricular tachycardia22653970PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANKCNH2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KCNH2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionIEAbiological_process
GO:0071805potassium ion transmembrane transportIDAbiological_process
GO:0006811ion transportIEAbiological_process
GO:0005635nuclear envelopeIEAcellular_component
GO:0000155phosphorelay sensor kinase activityIEAmolecular_function
GO:0008076voltage-gated potassium channel complexTAScellular_component
GO:0006936muscle contractionTASbiological_process
GO:0005249voltage-gated potassium channel activityIEAmolecular_function
GO:0006813potassium ion transportTASbiological_process
GO:0060307regulation of ventricular cardiac muscle cell membIEAbiological_process
GO:0000160phosphorelay signal transduction systemIEAbiological_process
GO:0008015blood circulationNASbiological_process
GO:0016020membraneIEAcellular_component
GO:0005249voltage-gated potassium channel activityIDAmolecular_function
GO:0071805potassium ion transmembrane transportIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008016regulation of heart contractionTASbiological_process
GO:0086091regulation of heart rate by cardiac conductionIEAbiological_process
GO:0086091regulation of heart rate by cardiac conductionIMPbiological_process
GO:0042391regulation of membrane potentialIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0055085transmembrane transportIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005251delayed rectifier potassium channel activityTASmolecular_function
GO:0005216ion channel activityIEAmolecular_function
GO:0004871signal transducer activityIEAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0005242inward rectifier potassium channel activityIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process


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