Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITAV_HUMAN
Description:integrin, alpha V [Source:HGNC Symbol;Acc:6150]
Location:chr2 q32.1
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y404KKGIVyIFNGRFG-GAPPhosphoSitePlus
S21LPLLLsGLLLPPhosphoSitePlus
S1046NGEGNsHPRD
T586KLTPItIFMEYHPRD; phosphoELM
S866LRIKIsSLQTTIntegrin_alpha2PhosphoSitePlus
Y591TIFMEyRLDYRIntegrin_alpha2PhosphoSitePlus
Y591TIFMEyRLDYRHPRD; phosphoELM
S1046NGEGNsET___PhosphoSitePlus
Y284TLGMVyIYDGKHPRD; phosphoELM
Y225EIVSKyDPNVYHPRD
T279PRAARtLGMVYFG-GAPPhosphoSitePlus
T1048EGNSEt_____PhosphoSitePlus; SysPTM
T279PRAARtLGMVYHPRD; phosphoELM
T1048EGNSHPRD; SysPTM

Dephosphorylation site
ITAV_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261023V347LCOSMICOvarian Cancer21720365
ENSP00000261023C711SBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000261023S501YCOSMICOvarian Cancer21720365
ENSP00000261023Q748*COSMICMelanoma21499247
ENSP00000261023L892FCOSMICHead and Neck Cancer21798893
ENSP00000261023S697FCOSMICHead and Neck Cancer21798893
ENSP00000261023L339RCOSMICRenal Cancer

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000261023Esophageal CancerNormal vs. CancertissueDown0.3119142970
ENSP00000261023Esophageal CancerNormal vs. CancertissueDown0.4119142970
ENSP00000261023Breast CancerMetastasiscell lineUp219321434

Hyperphosphorylation site
ITAV_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
OSTP_HUMANITAV_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05222Small cell lung cancer
hsa04514Cell adhesion molecules (CAMs)
hsa05200Pathways in cancer
hsa04810Regulation of actin cytoskeleton
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04510Focal adhesion
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa05414Dilated cardiomyopathy
hsa04512ECM-receptor interaction
hsa04145Phagosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009897external side of plasma membraneIEAcellular_component
GO:0007155cell adhesionIDAbiological_process
GO:0001846opsonin bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0070588calcium ion transmembrane transportIDAbiological_process
GO:0005245voltage-gated calcium channel activityIDAmolecular_function
GO:0070371ERK1 and ERK2 cascadeISSbiological_process
GO:0045785positive regulation of cell adhesionIDAbiological_process
GO:0001846opsonin bindingISSmolecular_function
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:2000425regulation of apoptotic cell clearanceIEAbiological_process
GO:0031994insulin-like growth factor I bindingIDAmolecular_function
GO:0016020membraneISScellular_component
GO:0046718viral entry into host cellTASbiological_process
GO:0050431transforming growth factor beta bindingISSmolecular_function
GO:0002479antigen processing and presentation of exogenous pTASbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0007229integrin-mediated signaling pathwayNASbiological_process
GO:0035867alphav-beta3 integrin-IGF-1-IGF1R complexIDAcellular_component
GO:0010745negative regulation of macrophage derived foam celIMPbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0033690positive regulation of osteoblast proliferationIEAbiological_process
GO:0007160cell-matrix adhesionNASbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0008305integrin complexNAScellular_component
GO:0007411axon guidanceTASbiological_process
GO:0032369negative regulation of lipid transportIMPbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0045715negative regulation of low-density lipoprotein parIMPbiological_process
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0009986cell surfaceISScellular_component
GO:0010888negative regulation of lipid storageIMPbiological_process
GO:0050764regulation of phagocytosisIDAbiological_process
GO:0070371ERK1 and ERK2 cascadeIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:2000425regulation of apoptotic cell clearanceISSbiological_process
GO:0050748negative regulation of lipoprotein metabolic proceIMPbiological_process
GO:0045335phagocytic vesicleTAScellular_component
GO:2000536negative regulation of entry of bacterium into hosIDAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0005887integral to plasma membraneNAScellular_component
GO:0043277apoptotic cell clearanceIEAbiological_process
GO:0052066entry of symbiont into host cell by promotion of hNASbiological_process
GO:0005080protein kinase C bindingISSmolecular_function
GO:0001525angiogenesisIEPbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0050900leukocyte migrationTASbiological_process
GO:0005080protein kinase C bindingIEAmolecular_function