| UniProt/SwissProt ID: | IRAK4_HUMAN |
| Description: | interleukin-1 receptor-associated kinase 4 [Source:HGNC Symbol;Acc:17967] |
| Location: | chr12 q12 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y430 | SVEAMySVASQ | Pkinase | PhosphoSitePlus |
| T345 | AQTVMtSRIVG | Pkinase | PhosphoSitePlus |
| S150 | YMPPDsSSPEN | PhosphoSitePlus; HPRD | |
| S336 | GLARAsEKFAQ | Pkinase | PhosphoSitePlus |
| S346 | QTVMTsRIVGT | Pkinase | PhosphoSitePlus |
| T6 | STYV | HPRD | |
| S114 | ANTLPsKEAIT | PhosphoSitePlus | |
| T6 | MNKPItPSTYV | PhosphoSitePlus | |
| S152 | PPDSSsPENKS | PhosphoSitePlus; HPRD; phosphoELM | |
| T342 | EKFAQtVMTSR | Pkinase | PhosphoSitePlus |
| T208 | GYVNNtTVAVK | Pkinase; Focal_AT | PhosphoSitePlus |
| S8 | KPITPsTYVRC | PhosphoSitePlus | |
| T209 | YVNNTtVAVKK | Pkinase; Focal_AT | PhosphoSitePlus |
| Y354 | VGTTAyMAPEA | Pkinase | PhosphoSitePlus |
| S151 | MPPDSsSPENK | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| IRAK4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000390651 | G255E | COSMIC | Lung Cancer | 20668451 | ENSP00000390651 | I53V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000390651 | E116Q | COSMIC | Breast Cancer | 20668451 | ENSP00000390651 | R288T | COSMIC | Breast Cancer | 20668451 | ENSP00000390651 | P266R | COSMIC | Ovarian Cancer | 20668451 |
| Differential expressed protein |
| IRAK4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IRAK4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IRAK4_HUMAN | IRAK1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05162 | Measles |
| hsa05152 | Tuberculosis |
| hsa04722 | Neurotrophin signaling pathway |
| hsa04064 | NF-kappa B signaling pathway |
| hsa05133 | Pertussis |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04210 | Apoptosis |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa05164 | Influenza A |
| hsa05145 | Toxoplasmosis |
| hsa05140 | Leishmaniasis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0010008 | endosome membrane | TAS | cellular_component |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0001816 | cytokine production | IEA | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathw | TAS | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004672 | protein kinase activity | EXP | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0000287 | magnesium ion binding | IEA | molecular_function |
| GO:0008063 | Toll signaling pathway | TAS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0034142 | toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034130 | toll-like receptor 1 signaling pathway | TAS | biological_process |
| GO:0007254 | JNK cascade | IEA | biological_process |
| GO:0048661 | positive regulation of smooth muscle cell prolifer | IEA | biological_process |
| GO:0034134 | toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0002224 | toll-like receptor signaling pathway | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005149 | interleukin-1 receptor binding | IEA | molecular_function |