| UniProt/SwissProt ID: | IPYR_HUMAN |
| Description: | pyrophosphatase (inorganic) 1 [Source:HGNC Symbol;Acc:9226] |
| Location: | chr10 q22.1 |
| Node attribute: | phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y17 | PFSLEyRVFLK | PhosphoSitePlus | |
| S5 | EERA | HPRD | |
| Y94 | GYIWNyGAIPQ | Pyrophosphatase | PhosphoSitePlus |
| S2 | ____MsGFSTE | PhosphoSitePlus | |
| S2 | FSTE | HPRD | |
| Y38 | HDIPIyADKDV | PhosphoSitePlus | |
| T6 | ERAA | HPRD | |
| T6 | MSGFStEERAA | PhosphoSitePlus | |
| S250 | TTLSEsPFKCD | PhosphoSitePlus; HPRD | |
| Y28 | NEKGQyISPFH | PhosphoSitePlus | |
| S5 | _MSGFsTEERA | PhosphoSitePlus | |
| Dephosphorylation site |
| IPYR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362329 | K57N | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000362329 | C242F | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000362329 | hepatitis C virus | Normal vs. Cancer | tissue | Down | 0.4 | 18715028 | ENSP00000362329 | colorectal cancer | Normal vs. Cancer | tissue | Up | 2 | 14997500 | ENSP00000362329 | Breast Cancer | Normal vs. Cancer | cell line | Up | 7 | 14997480 | ENSP00000362329 | Breast Cancer | Normal vs. Cancer | cell line | Up | 3 | 14997480 | ENSP00000362329 | Breast Cancer | Treatment (none vs. multidrug resistant) | cell line | Down | 0.53 | 16540677 | ENSP00000362329 | hepatitis B virus | Normal vs. Cancer | tissue | Up | 2.8 | 17671684 | ENSP00000362329 | Gastric Cancer | Treatment (none vs. Vincristine-resistant) | cell line | Up | 16525997 | ENSP00000362329 | Gastric Cancer | Treatment (none vs. Vincristine-resistant) | cell line | Up | 1.8 | 18253933 | ENSP00000362329 | Breast Cancer | Normal vs. Cancer | tissue | Up | 9.8 | 20005186 | ENSP00000362329 | Breast Cancer | Normal vs. Cancer | tissue | Up | >10 | 20005186 | ENSP00000362329 | Ovarian Cancer | Normal vs. Cancer | cell line | Down | 0.5 | 15591324 | ENSP00000362329 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | <2 | 15526344 | ENSP00000362329 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Up | 2 | 20625496 | ENSP00000362329 | Uterine Cancer | Cancer vs. Cancer | cell line | Up | 17616526 |
| Hyperphosphorylation site |
| IPYR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IPYR_HUMAN | ANDR_HUMAN | phosphatase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00190 | Oxidative phosphorylation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006418 | tRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0005737 | cytoplasm | TAS | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004427 | inorganic diphosphatase activity | EXP | molecular_function |
| GO:0071344 | diphosphate metabolic process | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0016462 | pyrophosphatase activity | IEA | molecular_function |
| GO:0000287 | magnesium ion binding | IEA | molecular_function |
| GO:0006796 | phosphate-containing compound metabolic process | IEA | biological_process |