Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:INCE_HUMAN
Description:inner centromere protein antigens 135/155kDa [Source:HGNC Symbol;Acc:6058]
Location:chr11 q12.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S919SSLAYsLKphosphoELM; SysPTM
S208ATAPTsQGIPTPhosphoSitePlus; phosphoELM
S263RIAQVsPGPRDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S914SSLAYsLKKH_PhosphoSitePlus
S148SPTPEsPTMLTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y909PSSLAySLKHPRD
T412EIANStPNPKPPhosphoSitePlus; HPRD
Y913PSSLAySLKKHPhosphoSitePlus
S794TVDVQsPACTSHPRD
T840RKPIPtWARGTHPRD
Y822INPDNyGMDLNPhosphoSitePlus; HPRD
S300GSRTDsQSVRHPhosphoSitePlus; HPRD; phosphoELM
T406WPHNDtEIANSPhosphoSitePlus; HPRD
S893YHKRTsSAVWNPhosphoSitePlus; HPRD
S323LAQKYsLVAKQHPRD
S898YHKRTsSAVWNphosphoELM; RegPhos
S93RRKSRsSQLSSPhosphoSitePlus; HPRD; SysPTM
T145APSSPtPESPTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S314APSSPsPQVLAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S836LNSDDsTDDEAphosphoELM; RegPhos
T59ELMPKtPSQKNPhosphoSitePlus
S910ARVPSsLAYSLPhosphoSitePlus
S452ARRKRsYKQAVPhosphoSitePlus
S910SSLAYsLKHPRD
S426SPETPsAGQQEHPRD
S296STPTGsRTDSQPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S799SPACTsYQMTPHPRD
S306QSVRHsPIAPSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S91LSRRKsRSSQLPhosphoSitePlus; HPRD; SysPTM
S106LRSKDsVEKLAHPRD
T294NFSTPtGSRTDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T509MLMTPtSAPRSPhosphoSitePlus; HPRD; phosphoELM
S411TEIANsTPNPKPhosphoSitePlus; HPRD
T298PTGSRtDSQSVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S400NNGNNsWPHNDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S330VAKQEsVVRRAPhosphoSitePlus; HPRD
T478PPRSKtPSSPCPhosphoSitePlus; HPRD
S202SPTPAsATAPTPhosphoSitePlus; HPRD; phosphoELM
S476LQPPRsKTPSSPhosphoSitePlus; HPRD; SysPTM
S275PAFPDsPWRERPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T837NSDDStDDEAHphosphoELM; RegPhos
S421KPAASsPETPSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S50FTREFsKEPELHPRD
S899HKRTSsAVWNSAurora BphosphoELM
S253VGTGRsASKLRPhosphoSitePlus
S336VVRRAsRRLAKPhosphoSitePlus
T798QSPACtSYQMTHPRD
S458YKQAVsELDEEPhosphoSitePlus; HPRD; SysPTM
S890HKRTSsAVWNSAURKBHPRD
T844RKPIPtWARGTHPRD
T213SQGIPtSDEESPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S218TSDEEsTPKKSPhosphoSitePlus; HPRD; phosphoELM
T793KALNVtVDVQSHPRD
S909GARVPsSLAYSPhosphoSitePlus
T828NSDDStDDEAHHPRD
Y818INPDNyGMDLNHPRD
T892RYHKRtSSAVWPhosphoSitePlus; HPRD
S486SPCPAsKVVRPPhosphoSitePlus
T897RYHKRtSSAVWAurora BphosphoELM
S214QGIPTsDEESTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S142ALAAPsSPTPEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T195EPLPRtLSPTPPhosphoSitePlus; HPRD; phosphoELM
Y322VLAQKySLVAKHPRD
T150TPESPtMLTKKPhosphoSitePlus; HPRD; phosphoELM
S898YHKRTsSAVWNAurora BphosphoELM
S833GMDLNsDDSTDphosphoELM; RegPhos
S94RKSRSsQLSSRPhosphoSitePlus; HPRD
S197LPRTLsPTPASPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T498RTFLHtVQRNQPhosphoSitePlus
S350EEPAAsGRIICHPRD
T153SPTMLtKKPEDHPRD; phosphoELM
S234ESITVsSLMATPhosphoSitePlus
T789KALNVtVDVQSHPRD
T802QSPACtSYQMTHPRD
S904SAVWNsPPLQGphosphoELM; RegPhos; SysPTM
S899HKRTSsAVWNSAurB(Aurora BRegPhos
S898YHKRTsSAVWNAurB(Aurora BRegPhos
T292PDNFStPTGSRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T832NSDDStDDEAHINCENP_ARK-bindPhosphoSitePlus
S914SSLAYsLKHPRD
S831LNSDDsTDDEAINCENP_ARK-bindPhosphoSitePlus
T207SATAPtSQGIPPhosphoSitePlus
T897RYHKRtSSAVWAurB(Aurora BRegPhos
S899HKRTSsAVWNSphosphoELM; RegPhos
S446REPPQsARRKRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S808SPACTsYQMTPphosphoELM
S420PKPAAsSPETPPhosphoSitePlus; HPRD
T239SSLMAtPQDPKPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T232ILESItVSSLMPhosphoSitePlus; HPRD; phosphoELM
T424ASSPEtPSAGQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S255TGRSAsKLRIAPhosphoSitePlus; HPRD; phosphoELM
S798TVDVQsPACTSPhosphoSitePlus; HPRD
S312PIAPSsPSPQVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T832NSDDStDDEAHHPRD
S143LAAPSsPTPESPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T888RYHKRtSSAVWAURKBHPRD
S103SRRLRsKDSVEPhosphoSitePlus; HPRD; SysPTM
T844RKPIPtWARGTINCENP_ARK-bindPhosphoSitePlus
S230ARILEsITVSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S373PQKVGsEQKEPHPRD
S480RSKTPsSPCPAPhosphoSitePlus; HPRD
S889DIFKKsKPRYHAurBRegPhos
S895SAVWNsPPLQGHPRD
T897RYHKRtSSAVWAurBRegPhos
T897RYHKRtSSAVWRegPhos
S481SKTPSsPCPASPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S889YHKRTsSAVWNAURKBHPRD
T507NQMLMtPTSAPPhosphoSitePlus; HPRD; phosphoELM
S514TSAPRsVMKSFPhosphoSitePlus; HPRD; phosphoELM
S302RTDSQsVRHSPPhosphoSitePlus; phosphoELM
S828GMDLNsDDSTDHPRD
T219SDEEStPKKSKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S291LPDNFsTPTGSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T199RTLSPtPASATPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S119VGENGsVLRRVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S899SAVWNsPPLQGPhosphoSitePlus; HPRD
T250GQGVGtGRSASPhosphoSitePlus; HPRD
S72KKRRIsYVQDEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S235SITVSsLMATPPhosphoSitePlus; HPRD; phosphoELM
T204TPASAtAPTSQPhosphoSitePlus; HPRD
S831LNSDDsTDDEAHPRD
S824GMDLNsDDSTDHPRD
S894HKRTSsAVWNSPhosphoSitePlus; HPRD
S803SPACTsYQMTPHPRD
S899HKRTSsAVWNSAurBRegPhos
Y913PSSLAySLKHPRD
S311SPIAPsSPSPQPhosphoSitePlus; HPRD; phosphoELM
S510LMTPTsAPRSVPhosphoSitePlus; HPRD; phosphoELM
S827LNSDDsTDDEAHPRD
S828GMDLNsDDSTDINCENP_ARK-bindPhosphoSitePlus
Y73KRRISyVQDENPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S357RIICHsYLERLHPRD
S269PGPRDsPAFPDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S223STPKKsKARILPhosphoSitePlus

Dephosphorylation site
INCE_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000278849A344PBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000278849S910RBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
INCE_HUMAN is not differential expressed protein.

Hyperphosphorylation site
INCE_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANINCE_HUMANkinase -> substrateRegPhos
AURKB_HUMANINCE_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
INCE_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0005874microtubuleIEAcellular_component
GO:0000775chromosome, centromeric regionIDAcellular_component
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0005721centromeric heterochromatinIDAcellular_component
GO:0005819spindleIDAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0000910cytokinesisIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0000236mitotic prometaphaseTASbiological_process
GO:0000777condensed chromosome kinetochoreIEAcellular_component
GO:0000801central elementIEAcellular_component
GO:0030496midbodyIEAcellular_component
GO:0000800lateral elementIEAcellular_component
GO:0000776kinetochoreIDAcellular_component
GO:0043234protein complexIDAcellular_component
GO:0000795synaptonemal complexIEAcellular_component
GO:0010369chromocenterIEAcellular_component
GO:0007059chromosome segregationIMPbiological_process