| UniProt/SwissProt ID: | IL2RG_HUMAN |
| Description: | interleukin 2 receptor, gamma [Source:HGNC Symbol;Acc:6010] |
| Location: | chrX q13.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y303 | DLVTEyHGNFS | PhosphoSitePlus; HPRD | |
| S308 | YHGNFsAWSGV | PhosphoSitePlus | |
| Y325 | SLQPDySERLC | PhosphoSitePlus | |
| Y363 | WAPPCyTLKP | HPRD | |
| T301 | LEDLVtEYHGN | PhosphoSitePlus | |
| S326 | LQPDYsERLCL | PhosphoSitePlus | |
| Y357 | NQHSPyWAPPC | PhosphoSitePlus; HPRD | |
| T292 | MPRIPtLKNLE | PhosphoSitePlus | |
| Y363 | WAPPCyTLKPE | PhosphoSitePlus | |
| Dephosphorylation site |
| IL2RG_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363318 | R218C | COSMIC | Pancreatic Cancer | ENSP00000363318 | R218C | COSMIC | Pancreatic Cancer |
| Differential expressed protein |
| IL2RG_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IL2RG_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IL2RG_HUMAN | P85A_HUMAN | kinase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04144 | Endocytosis |
| hsa05162 | Measles |
| hsa04630 | Jak-STAT signaling pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa05340 | Primary immunodeficiency |
| hsa05166 | HTLV-I infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019976 | interleukin-2 binding | ISS | molecular_function |
| GO:0004896 | cytokine receptor activity | IEA | molecular_function |
| GO:0004917 | interleukin-7 receptor activity | TAS | molecular_function |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0004911 | interleukin-2 receptor activity | TAS | molecular_function |
| GO:0038110 | interleukin-2-mediated signaling pathway | TAS | biological_process |
| GO:0009897 | external side of plasma membrane | ISS | cellular_component |
| GO:0038111 | interleukin-7-mediated signaling pathway | TAS | biological_process |
| GO:0004913 | interleukin-4 receptor activity | TAS | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0035771 | interleukin-4-mediated signaling pathway | TAS | biological_process |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |