| UniProt/SwissProt ID: | I17RB_HUMAN |
| Description: | interleukin 17 receptor B [Source:HGNC Symbol;Acc:18015] |
| Location: | chr3 p21.1 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T321 | ERIKKtSFSTT | PhosphoSitePlus | |
| Y310 | LVAGIyLMWRH | TM | PhosphoSitePlus |
| Y447 | KYVVVyFREID | SEFIR | PhosphoSitePlus |
| Y466 | SVCPKyHLMKD | SEFIR | PhosphoSitePlus |
| Dephosphorylation site |
| I17RB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000288167 | G43E | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000288167 | V22I | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| I17RB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| I17RB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IL17B_HUMAN | I17RB_HUMAN | ligand -> receptor | HPMR |
| IL25_HUMAN | I17RB_HUMAN | ligand -> receptor | HPMR |
| IL25_HUMAN | I17RB_HUMAN | other | KEGG |
| IL17B_HUMAN | I17RB_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0004896 | cytokine receptor activity | NAS | molecular_function |
| GO:0016020 | membrane | NAS | cellular_component |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0006952 | defense response | TAS | biological_process |
| GO:0001558 | regulation of cell growth | NAS | biological_process |
| GO:0009986 | cell surface | IEA | cellular_component |
| GO:0019221 | cytokine-mediated signaling pathway | NAS | biological_process |