| UniProt/SwissProt ID: | HPCA_HUMAN |
| Description: | hippocalcin [Source:HGNC Symbol;Acc:5144] |
| Location: | chr1 p35.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S143 | MPEDEsTPEKR | PhosphoSitePlus | |
| Y115 | LDGNGyISREE | efhand | PhosphoSitePlus |
| S191 | DPSSAsQF___ | PhosphoSitePlus | |
| T144 | PEDEStPEKRT | PhosphoSitePlus | |
| Y129 | IVQAIyKMVSS | PhosphoSitePlus | |
| Dephosphorylation site |
| HPCA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362566 | E120Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362566 | S93L | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000362566 | Breast Cancer | Normal vs. Cancer | cell line | Up | 7.4 | 20198662 | ENSP00000362566 | Breast Cancer | Metastasis | cell line | Down | 0.26 | 20198662 |
| Hyperphosphorylation site |
| HPCA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | HPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| HPCA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003779 | actin binding | IDA | molecular_function |
| GO:0005509 | calcium ion binding | NAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0048839 | inner ear development | IEA | biological_process |