| UniProt/SwissProt ID: | HIPK3_HUMAN |
| Description: | homeodomain interacting protein kinase 3 [Source:HGNC Symbol;Acc:4915] |
| Location: | chr11 p13 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y359 | TVCSTyLQSRY | Pkinase | PhosphoSitePlus |
| T358 | KTVCStYLQSR | Pkinase | PhosphoSitePlus |
| Y8 | SQVLVyPPYVY | PhosphoSitePlus | |
| S357 | SKTVCsTYLQS | Pkinase | PhosphoSitePlus |
| Y466 | KEARKyIFNSL | Pkinase | PhosphoSitePlus |
| T156 | PAMLQtNMGNP | PhosphoSitePlus | |
| S362 | STYLQsRYYRA | Pkinase | PhosphoSitePlus |
| S1205 | TGFPLsPTKLS | PhosphoSitePlus | |
| Y359 | TVCSTyLQSRY | HPRD; phosphoELM | |
| T219 | CWKRGtNEIVA | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| HIPK3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000398241 | R431I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000368301 | R431I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000431710 | R431I | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| HIPK3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HIPK3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HIPK3_HUMAN | FADD_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| HIPK3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005524 | ATP binding | NAS | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0018107 | peptidyl-threonine phosphorylation | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IMP | biological_process |
| GO:0009299 | mRNA transcription | IDA | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0043508 | negative regulation of JUN kinase activity | IEA | biological_process |
| GO:0009103 | lipopolysaccharide biosynthetic process | IEA | biological_process |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0018105 | peptidyl-serine phosphorylation | IEA | biological_process |
| GO:0004672 | protein kinase activity | IDA | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |