Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HGS_HUMAN
Description:hepatocyte growth factor-regulated tyrosine kinase substrate [Source:HGNC Symbol;Acc:4897]
Location:chr17 q25.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T347ARKSPtPSAPVPhosphoSitePlus
S284RLRQKsTYTSYPhosphoSitePlus
T239PPEYLtSPLSQPhosphoSitePlus
Y132VVQDTyQIMKVVHSPhosphoSitePlus
T625PSMPStAADPSHPRD
Y216VCEPCyEQLNRFYVEPhosphoSitePlus
Y308PASSLySSPVNPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S246PLSQQsQLPPKPhosphoSitePlus
Y466DERRLyYEGLQHrs_helicalPhosphoSitePlus
Y132VVQDTyQIMKVHPRD; phosphoELM
T287QKSTYtSYPKAPhosphoSitePlus
S288KSTYTsYPKAEPhosphoSitePlus
T228AEGKAtSTTELPhosphoSitePlus
S306APPASsLYSSPPhosphoSitePlus
S240PEYLTsPLSQQPhosphoSitePlus; HPRD; SysPTM
Y329PELARyLNRNYEGFRHPRD; phosphoELM; RegPhos
S198CSSKYsTIPKFHPRD
S345EEARKsPTPSAPhosphoSitePlus; HPRD
Y237ELPPEyLTSPLPhosphoSitePlus
S305SAPPAsSLYSSPhosphoSitePlus
Y125RNEPKyKVVQDVHSPhosphoSitePlus
Y524QKKQEyLEVQRPhosphoSitePlus
Y286RQKSTyTSYPKPhosphoSitePlus
Y567AFPLPyAQLQAHPRD
S310SSLYSsPVNSSHPRD; phosphoELM
Y334YLNRNyWEKKQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y329PELARyLNRNYPhosphoSitePlus; RegPhos
S594FPSTFsPAGSVHPRD
T131KVVQDtYQIMKVHSPhosphoSitePlus
Y216VCEPCyEQLNRHPRD; phosphoELM; RegPhos
Y467ERRLYyEGLQDHrs_helicalPhosphoSitePlus
Y289STYTSyPKAEPPhosphoSitePlus
S243LTSPLsQQSQLPhosphoSitePlus
S309ASSLYsSPVNSPhosphoSitePlus

Dephosphorylation site
HGS_HUMAN do not have dephosphorylation site.

Mutation site
HGS_HUMAN do not have mutation site.

Differential expressed protein
HGS_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HGS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANHGS_HUMANkinase -> substrateRegPhos
EGFR_HUMANHGS_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04145Phagosome
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032585multivesicular body membraneIEAcellular_component
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0005769early endosomeIDAcellular_component
GO:0016020membraneIEAcellular_component
GO:0046426negative regulation of JAK-STAT cascadeIDAbiological_process
GO:0008333endosome to lysosome transportIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0016044cellular membrane organizationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0019904protein domain specific bindingIPImolecular_function
GO:0005768endosomeIDAcellular_component
GO:0042176regulation of protein catabolic processTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0016197endosomal transportNASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0031901early endosome membraneIEAcellular_component
GO:0006886intracellular protein transportIEAbiological_process
GO:0030141secretory granuleIEAcellular_component