Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HGF_HUMAN
Description:hepatocyte growth factor (hepapoietin A; scatter factor) [Source:HGNC Symbol;Acc:4893]
Location:chr7 q21.11
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T48KKSAKtTLIKIPAN_1PhosphoSitePlus
S45R.NTIHEFKKSAKTTLIK.ISysPTM 2.0

Dephosphorylation site
HGF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000222390G254DCOSMICSkin Cancer21984974
ENSP00000222390Y272CCOSMICHepatocellular Carcinoma21822264
ENSP00000222390Y619CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000222390G520*COSMICOvarian Cancer21720365
ENSP00000391238E665XBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000222390W329*COSMICOvarian Cancer21720365
ENSP00000222390R695HCOSMICCentral Nervous System Neoplasms18772890
ENSP00000391238Y614CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000222390E199KCOSMICSkin Cancer21984974
ENSP00000222390E656KCOSMICSkin Cancer21984974

Differential expressed protein
HGF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HGF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HGF_HUMANSLTM_HUMANligand -> receptorHPMR
HGF_HUMANSLTM_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04510Focal adhesion
hsa05218Melanoma
hsa05211Renal cell carcinoma
hsa05144Malaria
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035729cellular response to hepatocyte growth factor stimIDAbiological_process
GO:0050918positive chemotaxisIDAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0000187activation of MAPK activityIEAbiological_process
GO:0000902cell morphogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001889liver developmentIEAbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0051450myoblast proliferationIEAbiological_process
GO:0001837epithelial to mesenchymal transitionTASbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0042056chemoattractant activityIDAmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0060326cell chemotaxisIDAbiological_process
GO:2000573positive regulation of DNA biosynthetic processIDAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0090201negative regulation of release of cytochrome c froIDAbiological_process
GO:0060665regulation of branching involved in salivary glandIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0045669positive regulation of osteoblast differentiationNASbiological_process
GO:1901299negative regulation of hydrogen peroxide-mediated IDAbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0048012hepatocyte growth factor receptor signaling pathwaIEAbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0031100organ regenerationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyNASbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0007067mitosisNASbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0004252serine-type endopeptidase activityIEAmolecular_function
GO:0030335positive regulation of cell migrationIDAbiological_process


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