| UniProt/SwissProt ID: | HEM3_HUMAN |
| Description: | hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:4982] |
| Location: | chrHG299_PATCH q23.3 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S262 | LEGGCsVPVAV | Porphobil_deamC | PhosphoSitePlus |
| S15 | TAEENsPKMRV | HPRD | |
| T269 | PVAVHtAMKDG | Porphobil_deamC | PhosphoSitePlus |
| Dephosphorylation site |
| HEM3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| HEM3_HUMAN do not have mutation site. |
| Differential expressed protein |
| HEM3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HEM3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GATA1_HUMAN | HEM3_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| HEM3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006778 | porphyrin-containing compound metabolic process | TAS | biological_process |
| GO:0006783 | heme biosynthetic process | IC | biological_process |
| GO:0004418 | hydroxymethylbilane synthase activity | IEA | molecular_function |
| GO:0006782 | protoporphyrinogen IX biosynthetic process | IEA | biological_process |
| GO:0033014 | tetrapyrrole biosynthetic process | IEA | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0018160 | peptidyl-pyrromethane cofactor linkage | IEA | biological_process |