Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRIA2_HUMAN
Description:glutamate receptor, ionotropic, AMPA 2 [Source:HGNC Symbol;Acc:4572]
Location:chr4 q32.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T291PGAHTtTIKYTANF_receptorPhosphoSitePlus
S880VYGIEsVPRKCAHPRD
S880VYGIEsVHPRD; phosphoELM
Y869QNFATyKEGYNRegPhos
S717ARVRKsKGKYAPRKCAHPRD
T279IERWStLEEKEANF_receptorPhosphoSitePlus
S880VYGIEsVKI__PhosphoSitePlus
S717ARVRKsKGKYAPKCaRegPhos
S683EFFRRsKIAVFPKCaRegPhos
S880VYGIEsVKIPKCaRegPhos
T292GAHTTtIKYTSANF_receptorPhosphoSitePlus
S683EFFRRsKIAVFPKC_groupRegPhos
S880VYGIEsVKIRegPhos
S717ARVRKsKGKYAPKG_groupRegPhos
Y285LEEKEyPGAHTANF_receptorPhosphoSitePlus
Y876EGYNVyGIESVRegPhos
S683EFFRRsKIAVFPRKCAHPRD

Dephosphorylation site
GRIA2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296526P383RCOSMICHead and Neck Cancer21798893
ENSP00000296526E879KCOSMICSkin Cancer21984974
ENSP00000264426K677EBIOMARTBreast Cancer21930507, 21930502
ENSP00000296526S82LCOSMICSkin Cancer21984974
ENSP00000296526G520WBIOMARTBreast Cancer21930507, 21930502
ENSP00000296526L829PCOSMICHead and Neck Cancer21798893
ENSP00000264426I819MBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000296526K677EBIOMARTBreast Cancer21930507, 21930502
ENSP00000296526E793KCOSMICHead and Neck Cancer21798893
ENSP00000296526E377VCOSMICOvarian Cancer21720365
ENSP00000264426G520WBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
GRIA2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRIA2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANGRIA2_HUMANkinase -> substrateRegPhos
KPCA_HUMANGRIA2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04730Long-term depression
hsa04723Retrograde endocannabinoid signaling
hsa04728Dopaminergic synapse
hsa04720Long-term potentiation
hsa04080Neuroactive ligand-receptor interaction
hsa05030Cocaine addiction
hsa04724Glutamatergic synapse
hsa05033Nicotine addiction
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05031Amphetamine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004970ionotropic glutamate receptor activityIEAmolecular_function
GO:0008066glutamate receptor activityTASmolecular_function
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0035235ionotropic glutamate receptor signaling pathwayIDAbiological_process
GO:0007268synaptic transmissionIEAbiological_process
GO:0030054cell junctionIEAcellular_component
GO:0030288outer membrane-bounded periplasmic spaceIEAcellular_component
GO:0005215transporter activityIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0005887integral to plasma membraneISScellular_component
GO:0032281alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropioniIEAcellular_component
GO:0006810transportIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005234extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionISSmolecular_function
GO:0035235ionotropic glutamate receptor signaling pathwayIEAbiological_process
GO:0045211postsynaptic membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0015277kainate selective glutamate receptor activityISSmolecular_function
GO:0030666endocytic vesicle membraneTAScellular_component


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