Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GIT2_HUMAN
Description:G protein-coupled receptor kinase interacting ArfGAP 2 [Source:HGNC Symbol;Acc:4273]
Location:chr12 q24.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T481RKQATtNVYQVDUF972; DUF2570PhosphoSitePlus
T401ASDEDtDLETTPhosphoSitePlus
S394QPDYDsVASDEPhosphoSitePlus; HPRD; phosphoELM
S408LETTAsKTNRQPhosphoSitePlus
S596PGDPGsPTDVQHPRD
S568FPSTLsWSRDEPhosphoSitePlus
S514GSRPMsMYETGPhosphoSitePlus
S7SKRLRsSEVCAArfGapPhosphoSitePlus
S384QHSVEsQDNDQHPRD
T587EKQNStPESDYPhosphoSitePlus
S421LDSDLsDGPVTHPRD
Y392NDQPDyDSVASPhosphoSitePlus; HPRD; phosphoELM
T493TGSEYtDTSNHPhosphoSitePlus
S418QKSLDsDLSDGHAP1_NPhosphoSitePlus
S415TNRQKsLDSDLHAP1_NPhosphoSitePlus
T405DTDLEtTASKTPhosphoSitePlus
S586LEKQNsTPESDPhosphoSitePlus
S559VTSSSsLPSFPPhosphoSitePlus; phosphoELM
S590NSTPEsDYDNTPhosphoSitePlus
T488VYQVQtGSEYTDUF2570PhosphoSitePlus
T495SEYTDtSNHSSPhosphoSitePlus
S496EYTDTsNHSSLPhosphoSitePlus; HPRD; phosphoELM
S486KGRQRsMVWPGHPRD
S532PMGEAsRPEESPhosphoSitePlus
S614KGRQRsMVWPGPhosphoSitePlus; HPRD; phosphoELM
S724PGDPGsPTDVQHPRD
S397YDSVAsDEDTDPhosphoSitePlus; HPRD; phosphoELM
T480LRKQAtTNVYQHAP1_N; DUF972; DUF2570PhosphoSitePlus
S570STLSWsRDESAPhosphoSitePlus
S562SSSLPsFPSTLPhosphoSitePlus
Y516RPMSMyETGSGPhosphoSitePlus
Y592TPESDyDNTPNPhosphoSitePlus
S506LKRRPsARGSRPhosphoSitePlus
Y484ATTNVyQVQTGHPRD; phosphoELM
S490QVQTGsEYTDTPhosphoSitePlus
T406TDLETtASKTNPhosphoSitePlus
Y525SGQKPyLPMGEPhosphoSitePlus
S500TSNHSsLKRRPPhosphoSitePlus
T488VYQVQtGSEYTHPRD; phosphoELM
S421LDSDLsDGPVTHAP1_NPhosphoSitePlus
S418QKSLDsDLSDGHPRD
S381INNQHsVESQDHPRD
Y492QTGSEyTDTSNPhosphoSitePlus; HPRD; phosphoELM
S668ENKHDsYIPCSGIT1_CPhosphoSitePlus
S415TNRQKsLDSDLHPRD
Y484ATTNVyQVQTGDUF972; DUF2570PhosphoSitePlus
S673SYIPCsERIHVGIT1_CPhosphoSitePlus

Dephosphorylation site
GIT2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000347464M615ICOSMICSkin Cancer21984974
ENSP00000347464S360NCOSMICCentral Nervous System Neoplasms18772396
ENSP00000354282*730YCOSMICLung Cancer18948947

Differential expressed protein
GIT2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GIT2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AURKB_HUMANGIT2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
GIT2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0008277regulation of G-protein coupled receptor protein sTASbiological_process
GO:0032312regulation of ARF GTPase activityIEAbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0008060ARF GTPase activator activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function