| UniProt/SwissProt ID: | GFI1B_HUMAN |
| Description: | growth factor independent 1B transcription repressor [Source:HGNC Symbol;Acc:4238] |
| Location: | chr9 q34.13 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T245 | LIHSDtRPYPC | PhosphoSitePlus | |
| Y156 | DFSLRySPGMD | Rpr2 | PhosphoSitePlus |
| S157 | FSLRYsPGMDA | Rpr2 | PhosphoSitePlus |
| S41 | RDQAPsNSPVL | PhosphoSitePlus | |
| S261 | RFHQKsDMKKH | HPRD; SysPTM | |
| S233 | AFKRSsTLSTH | zf-C2H2 | PhosphoSitePlus |
| S243 | HLLIHsDTRPY | PhosphoSitePlus | |
| Dephosphorylation site |
| GFI1B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000409546 | R231H | BIOMART, HPI | Colorectal Cancer | 21930507, 21930502, 16959974 | ENSP00000344782 | R231H | HPI | Colorectal Cancer | 16959974 | ENSP00000361195 | D318N | COSMIC | Ovarian Cancer | 20826764 | ENSP00000344782 | R231H | Sjoblom2006 | Intestines Cancer | 16959974 | ENSP00000361195 | R231H | HPI | Colorectal Cancer | 16959974 | ENSP00000361195 | R231H | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| GFI1B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GFI1B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GFI1_MOUSE | GFI1B_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| GFI1B_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000114 | regulation of transcription involved in G1 phase o | TAS | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0005667 | transcription factor complex | IDA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0016363 | nuclear matrix | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0001085 | RNA polymerase II transcription factor binding | IPI | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | TAS | biological_process |
| GO:0016568 | chromatin modification | IEA | biological_process |
| GO:0007275 | multicellular organismal development | IEA | biological_process |