| UniProt/SwissProt ID: | GBRG2_HUMAN |
| Description: | gamma-aminobutyric acid (GABA) A receptor, gamma 2 [Source:HGNC Symbol;Acc:4087] |
| Location: | chr5 q34 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S366 | SNRKPsKDKDK | PKC_group | phosphoELM; RegPhos |
| S234 | VGDTRsWRLYQ | Neur_chan_LBD | PhosphoSitePlus |
| Y444 | AKMDSyARIFF | Neur_chan_memb; TM | PhosphoSitePlus |
| S366 | SNRKPsKDKDK | PRKCA | HPRD |
| S366 | SNRKPsKDKDK | PKC_epsilon | phosphoELM |
| Y238 | RSWRLyQFSFV | Neur_chan_LBD | PhosphoSitePlus |
| S226 | QWKRSsVEVGD | PKCa | RegPhos |
| S42 | FTSQKsDDDYE | PhosphoSitePlus | |
| S366 | SNRKPsKDKDK | PKCa | RegPhos |
| Y49 | DDYEDyASNKT | PhosphoSitePlus | |
| Y46 | KSDDDyEDYAS | PhosphoSitePlus | |
| Dephosphorylation site |
| GBRG2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000354651 | S348C | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000349000 | D123N | COSMIC | Skin Cancer | 21984974 | ENSP00000349000 | S348C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000349000 | S226Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000349000 | Y452C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000349000 | K328N | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000349000 | V219A | COSMIC | Skin Cancer | 21984974 | ENSP00000349000 | R82W | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| GBRG2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GBRG2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | GBRG2_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa05033 | Nicotine addiction |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04727 | GABAergic synapse |
| hsa05032 | Morphine addiction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032590 | dendrite membrane | ISS | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0006811 | ion transport | IEA | biological_process |
| GO:0004890 | GABA-A receptor activity | IEA | molecular_function |
| GO:0006821 | chloride transport | IEA | biological_process |
| GO:0051932 | synaptic transmission, GABAergic | ISS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0034707 | chloride channel complex | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0005230 | extracellular ligand-gated ion channel activity | IEA | molecular_function |
| GO:0045211 | postsynaptic membrane | IEA | cellular_component |
| GO:0008503 | benzodiazepine receptor activity | TAS | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | IEA | biological_process |
| GO:0006810 | transport | TAS | biological_process |
| GO:0030054 | cell junction | IEA | cellular_component |
| GO:0005254 | chloride channel activity | IEA | molecular_function |
| GO:0034220 | ion transmembrane transport | TAS | biological_process |