Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GATA3_HUMAN
Description:GATA binding protein 3 [Source:HGNC Symbol;Acc:4172]
Location:chr10 p14
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y282DGTGHyLCNACGATAPhosphoSitePlus
Y344NACGLyYKLHNGATAPhosphoSitePlus
Y290NACGLyHKMNGGATAPhosphoSitePlus
T271CGATStPLWRRGATAPhosphoSitePlus
S308PKRRLsAARRAPhosphoSitePlus
S110SHHTAsPWNLSPhosphoSitePlus
Y186KECLKyQVPLPPhosphoSitePlus
S369RNRKMsSKSKKPhosphoSitePlus
S381KKVHDsLEDFPPhosphoSitePlus
S162PPKDVsPDPSLPhosphoSitePlus
S115SPWNLsPFSKTPhosphoSitePlus

Dephosphorylation site
GATA3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000341619M293KBIOMARTBreast Cancer21930507, 21930502
ENSP00000368632A146TTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000368632R367LCOSMICBreast Cancer15361840
ENSP00000368632L344FCOSMICBreast Cancer15361840
ENSP00000368632R367*COSMICBreast Cancer15361840
ENSP00000368632M294KBIOMARTBreast Cancer21930507, 21930502
ENSP00000368632S403FCOSMICCentral Nervous System Neoplasms18772890
ENSP00000368632A146TCOSMICCentral Nervous System Neoplasms18772890
ENSP00000368632S199FTCGAOvarian Cancer21720365, 18772890
ENSP00000368632M416ICOSMICOvarian Cancer20826764
ENSP00000368632S199FCOSMICOvarian Cancer21720365
ENSP00000341619R366LHPIBreast Cancer17224074

Differential expressed protein
GATA3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GATA3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ST17A_HUMANGATA3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
GATA3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001078RNA polymerase II core promoter proximal region seIMPmolecular_function
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0000977RNA polymerase II regulatory region sequence-speciIEAmolecular_function
GO:0003215cardiac right ventricle morphogenesisIEAbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeISSbiological_process
GO:2000611positive regulation of thyroid hormone generationIMPbiological_process
GO:0032754positive regulation of interleukin-5 productionIEAbiological_process
GO:0000790nuclear chromatinIDAcellular_component
GO:0061290canonical Wnt receptor signaling pathway involved IEAbiological_process
GO:0035898parathyroid hormone secretionIEAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0043523regulation of neuron apoptotic processIEAbiological_process
GO:2000146negative regulation of cell motilityIMPbiological_process
GO:0051569regulation of histone H3-K4 methylationIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0032753positive regulation of interleukin-4 productionIEAbiological_process
GO:0001823mesonephros developmentISSbiological_process
GO:0060037pharyngeal system developmentIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0042421norepinephrine biosynthetic processISSbiological_process
GO:0042493response to drugIEAbiological_process
GO:0060065uterus developmentISSbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0045064T-helper 2 cell differentiationIEAbiological_process
GO:0003281ventricular septum developmentISSbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0001046core promoter sequence-specific DNA bindingIDAmolecular_function
GO:2000734negative regulation of glial cell-derived neurotroIEAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0033600negative regulation of mammary gland epithelial ceIDAbiological_process
GO:0035457cellular response to interferon-alphaIEPbiological_process
GO:0061290canonical Wnt receptor signaling pathway involved ISSbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeIEAbiological_process
GO:0000902cell morphogenesisIEAbiological_process
GO:0006959humoral immune responseIEAbiological_process
GO:0000976transcription regulatory region sequence-specific IDAmolecular_function
GO:0032736positive regulation of interleukin-13 productionIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0050728negative regulation of inflammatory responseIMPbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0031929TOR signaling cascadeIEAbiological_process
GO:0048469cell maturationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0003215cardiac right ventricle morphogenesisISSbiological_process
GO:2000607negative regulation of cell proliferation involvedIEAbiological_process
GO:0009791post-embryonic developmentIEAbiological_process
GO:2000734negative regulation of glial cell-derived neurotroISSbiological_process
GO:0002572pro-T cell differentiationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0072107positive regulation of ureteric bud formationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0048485sympathetic nervous system developmentISSbiological_process
GO:0072107positive regulation of ureteric bud formationISSbiological_process
GO:0007165signal transductionISSbiological_process
GO:0005134interleukin-2 receptor bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0045582positive regulation of T cell differentiationIEAbiological_process
GO:2000703negative regulation of fibroblast growth factor reISSbiological_process
GO:0071353cellular response to interleukin-4IEPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0007411axon guidanceIEAbiological_process
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0003713transcription coactivator activityIEAmolecular_function
GO:0061085regulation of histone H3-K27 methylationIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:2000667positive regulation of interleukin-13 secretionIMPbiological_process
GO:0072001renal system developmentIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:2000607negative regulation of cell proliferation involvedISSbiological_process
GO:0071356cellular response to tumor necrosis factorIEPbiological_process
GO:0042421norepinephrine biosynthetic processIEAbiological_process
GO:0002088lens development in camera-type eyeIEAbiological_process
GO:0060676ureteric bud formationIEAbiological_process
GO:0031929TOR signaling cascadeISSbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0035799ureter maturationIEAbiological_process
GO:0001775cell activationIEAbiological_process
GO:0048646anatomical structure formation involved in morphogIEAbiological_process
GO:0048568embryonic organ developmentIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0001158enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0072178nephric duct morphogenesisIEAbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0048538thymus developmentIEAbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0030217T cell differentiationIEAbiological_process
GO:0071353cellular response to interleukin-4IEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0001071nucleic acid binding transcription factor activityIEAmolecular_function
GO:0060017parathyroid gland developmentIEAbiological_process
GO:0072182regulation of nephron tubule epithelial cell diffeIEAbiological_process
GO:0003281ventricular septum developmentIEAbiological_process
GO:0048872homeostasis of number of cellsIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0001709cell fate determinationISSbiological_process
GO:0072178nephric duct morphogenesisISSbiological_process
GO:0050852T cell receptor signaling pathwayISSbiological_process
GO:2000703negative regulation of fibroblast growth factor reIEAbiological_process
GO:0032753positive regulation of interleukin-4 productionISSbiological_process
GO:0071345cellular response to cytokine stimulusIEAbiological_process
GO:0001823mesonephros developmentIEAbiological_process
GO:2000683regulation of cellular response to X-rayIMPbiological_process
GO:0072179nephric duct formationIEAbiological_process
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0045786negative regulation of cell cycleIEAbiological_process
GO:0010332response to gamma radiationIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0072676lymphocyte migrationIDAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0060374mast cell differentiationIEAbiological_process
GO:0009967positive regulation of signal transductionIMPbiological_process
GO:0071837HMG box domain bindingIPImolecular_function
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0072182regulation of nephron tubule epithelial cell diffeISSbiological_process
GO:0010595positive regulation of endothelial cell migrationIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0048646anatomical structure formation involved in morphogISSbiological_process
GO:0001806type IV hypersensitivityIEAbiological_process
GO:0032703negative regulation of interleukin-2 productionIEAbiological_process
GO:0008285negative regulation of cell proliferationISSbiological_process
GO:0060676ureteric bud formationISSbiological_process
GO:0051897positive regulation of protein kinase B signaling IMPbiological_process
GO:0042035regulation of cytokine biosynthetic processISSbiological_process
GO:0003180aortic valve morphogenesisISSbiological_process
GO:2000352negative regulation of endothelial cell apoptotic IMPbiological_process
GO:0042035regulation of cytokine biosynthetic processIEAbiological_process
GO:0000987core promoter proximal region sequence-specific DNIDAmolecular_function
GO:0070888E-box bindingIDAmolecular_function
GO:0001071nucleic acid binding transcription factor activityIDAmolecular_function
GO:0001819positive regulation of cytokine productionIEAbiological_process
GO:0060037pharyngeal system developmentISSbiological_process
GO:0072179nephric duct formationISSbiological_process
GO:0043370regulation of CD4-positive, alpha-beta T cell diffIEAbiological_process
GO:0071599otic vesicle developmentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0045599negative regulation of fat cell differentiationIMPbiological_process
GO:0045582positive regulation of T cell differentiationISSbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:2000679positive regulation of transcription regulatory reIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006952defense responseTASbiological_process
GO:0072643interferon-gamma secretionIEAbiological_process
GO:0042472inner ear morphogenesisIEAbiological_process
GO:0045061thymic T cell selectionIEAbiological_process
GO:0008584male gonad developmentISSbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0032689negative regulation of interferon-gamma productionIEAbiological_process
GO:0043583ear developmentIMPbiological_process
GO:0048589developmental growthIEAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific IEAmolecular_function
GO:0071773cellular response to BMP stimulusIEAbiological_process
GO:0001709cell fate determinationIEAbiological_process
GO:0060231mesenchymal to epithelial transitionIDAbiological_process
GO:0043627response to estrogen stimulusIEPbiological_process
GO:0001822kidney developmentIMPbiological_process
GO:0048485sympathetic nervous system developmentIEAbiological_process
GO:0060065uterus developmentIEAbiological_process
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0045786negative regulation of cell cycleIMPbiological_process
GO:0009615response to virusIEPbiological_process
GO:0003180aortic valve morphogenesisIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:2000114regulation of establishment of cell polarityIEAbiological_process
GO:0035162embryonic hemopoiesisIEAbiological_process
GO:0008584male gonad developmentIEAbiological_process
GO:2000664positive regulation of interleukin-5 secretionIDAbiological_process
GO:0072602interleukin-4 secretionIEAbiological_process