Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FOXM1_HUMAN
Description:forkhead box M1 [Source:HGNC Symbol;Acc:3818]
Location:chr12 p13.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T719ANRSLtEGLVLHPRD; phosphoELM
T620SVLPRtPESWRPhosphoSitePlus; HPRD; phosphoELM
S451FGEGFsPLLPVPhosphoSitePlus
T662MDLSTtPLQSARegPhos
S704VPKPGsPEPQVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S702LAANRsLTEGLHPRD
S501EESSHsWEDSSPhosphoSitePlus
T649LPISStPSKSVCDK2HPRD
S638GGLDFsPVQTSPhosphoSitePlus
T611LPISStPSKSVCDK2HPRD; RegPhos
T658SVLPRtPESWRHPRD
T612ESWRLtPPAKVHPRD
T510SSQSPtPRPKKPhosphoSitePlus
T649LPISStPSKSVCDK1HPRD
S717LAANRsLTEGLPhosphoSitePlus; HPRD
S692VPFGNsSPSDIPhosphoSitePlus
T605SVLPRtPESWRHPRD
S724ILLDIsFPGLDHPRD
S191WLRKMsSDGLGPhosphoSitePlus
S739ILLDIsFPGLDPhosphoSitePlus; HPRD
S777ILLDIsFPGLDHPRD
S508EDSSQsPTPRPPhosphoSitePlus
S489LEEWPsPAPSFPhosphoSitePlus
T600GGPFKtPIKETPhosphoSitePlus
T757ANRSLtEGLVLHPRD
S742VPKPGsPEPQVHPRD
T611LPISStPSKSVCDK1HPRD
T665ESWRLtPPAKVHPRD
S522YSGLRsPTRCVPhosphoSitePlus
T611LPISStPSKSVCDC2RegPhos
T627ESWRLtPPAKVPhosphoSitePlus; HPRD; phosphoELM
T596LPISStPSKSVCDK1HPRD
T596LPISStPSKSVCDK2HPRD
S715DTMNDsLSKILHPRD
S689VPKPGsPEPQVHPRD
S768DTMNDsLSKILHPRD
S693PFGNSsPSDIDPhosphoSitePlus
T704ANRSLtEGLVLHPRD
S331PLDPGsPQLPEPhosphoSitePlus; HPRD; phosphoELM
S672APPLEsPQRLLPhosphoSitePlus
S755LAANRsLTEGLHPRD
S730DTMNDsLSKILPhosphoSitePlus; HPRD; phosphoELM
S4__MKTsPRRPLPhosphoSitePlus
T611LPISStPSKSVPhosphoSitePlus
S35EEPKRsPAQQEPhosphoSitePlus

Dephosphorylation site
FOXM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000342307R579KCOSMICMelanoma
ENSP00000352901E480KBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000342307E518KCOSMICCentral Nervous System Neoplasms

Differential expressed protein
FOXM1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FOXM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK2_HUMANFOXM1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANFOXM1_HUMANkinase -> substrateRegPhos
CDK1_HUMANFOXM1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
FOXM1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003677DNA bindingTASmolecular_function
GO:0008134transcription factor bindingIBAmolecular_function
GO:0007389pattern specification processIBAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0071156regulation of cell cycle arrestIMPbiological_process
GO:0090344negative regulation of cell agingIMPbiological_process
GO:0042127regulation of cell proliferationNASbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0007049cell cycleTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0001570vasculogenesisIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIBAmolecular_function
GO:0009790embryo developmentIBAbiological_process
GO:0051090regulation of sequence-specific DNA binding transcIBAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0001889liver developmentIBAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0001570vasculogenesisIBAbiological_process
GO:0000086G2/M transition of mitotic cell cycleIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0006978DNA damage response, signal transduction by p53 clIMPbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0006281DNA repairIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0032873negative regulation of stress-activated MAPK cascaIMPbiological_process
GO:0046578regulation of Ras protein signal transductionIMPbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0009888tissue developmentIBAbiological_process
GO:0003690double-stranded DNA bindingIBAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0019901protein kinase bindingIPImolecular_function
GO:0019904protein domain specific bindingIBAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005667transcription factor complexIBAcellular_component
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0001558regulation of cell growthTASbiological_process
GO:2000781positive regulation of double-strand break repairIMPbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:2000377regulation of reactive oxygen species metabolic prIMPbiological_process