Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FCERG_HUMAN
Description:Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide [Source:HGNC Symbol;Acc:3611]
Location:chr1 q23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y65KSDGVyTGLSTHPRD; phosphoELM; SysPTM
T66SDGVYtGLSTRITAMPhosphoSitePlus
Y65KSDGVyTGLSTITAMPhosphoSitePlus; SysPTM
T75TRNQEtYETLKITAMPhosphoSitePlus
Y76RNQETyETLKHHPRD; phosphoELM; SysPTM
S69VYTGLsTRNQEITAMPhosphoSitePlus
T66SDGVYtGLSTRHPRD
Y58AAITSyEKSDGPhosphoSitePlus
S69VYTGLsTRNQEHPRD
Y76RNQETyETLKHITAMPhosphoSitePlus; SysPTM
T78QETYEtLKHEKITAMPhosphoSitePlus

Dephosphorylation site
FCERG_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000289902N72YBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
FCERG_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y65ITAMYEKSDGVyTGLSTRNcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
LYN_HUMANFCERG_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05152Tuberculosis
hsa05310Asthma
hsa04664Fc epsilon RI signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002554serotonin secretion by plateletIEAbiological_process
GO:0030593neutrophil chemotaxisIEAbiological_process
GO:0032733positive regulation of interleukin-10 productionIEAbiological_process
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0042742defense response to bacteriumIEAbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0032755positive regulation of interleukin-6 productionIEAbiological_process
GO:0032760positive regulation of tumor necrosis factor produIEAbiological_process
GO:0019864IgG bindingIEAmolecular_function
GO:0019863IgE bindingIEAmolecular_function
GO:0001812positive regulation of type I hypersensitivityIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0001805positive regulation of type III hypersensitivityIEAbiological_process
GO:0045576mast cell activationIEAbiological_process
GO:0016064immunoglobulin mediated immune responseIEAbiological_process
GO:0043306positive regulation of mast cell degranulationIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0042590antigen processing and presentation of exogenous pIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0050766positive regulation of phagocytosisIEAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0002431Fc receptor mediated stimulatory signaling pathwayIEAbiological_process
GO:0001798positive regulation of type IIa hypersensitivityIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0050776regulation of immune responseIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0019886antigen processing and presentation of exogenous pIEAbiological_process
GO:0033026negative regulation of mast cell apoptotic processIEAbiological_process
GO:0006911phagocytosis, engulfmentIEAbiological_process
GO:0050778positive regulation of immune responseIEAbiological_process
GO:0032765positive regulation of mast cell cytokine productiIEAbiological_process
GO:0019767IgE receptor activityIEAmolecular_function
GO:0032998Fc-epsilon receptor I complexIEAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayIEAbiological_process
GO:0010543regulation of platelet activationIEAbiological_process
GO:0002283neutrophil activation involved in immune responseIEAbiological_process
GO:0007229integrin-mediated signaling pathwayIEAbiological_process