| UniProt/SwissProt ID: | FANCG_HUMAN |
| Description: | Fanconi anemia, complementation group G [Source:HGNC Symbol;Acc:3588] |
| Location: | chr9 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S383 | SEPRFsPPPSP | TPR_16 | PhosphoSitePlus |
| S387 | FSPPPsPPGPC | CDC2(CDK1 | RegPhos |
| S7 | SRQTTsVGSSC | PhosphoSitePlus; RegPhos | |
| T557 | FHLLQtLKRLD | TPR_11 | PhosphoSitePlus |
| S387 | FSPPPsPPGPC | TPR_16 | PhosphoSitePlus |
| S7 | GSSC | phosphoELM | |
| S387 | FSPPPsPPGPC | CDK1 | HPRD; phosphoELM |
| S383 | SEPRFsPPPSP | HPRD | |
| Dephosphorylation site |
| FANCG_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000367910 | A607T | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000367910 | A607T | HPI | Colorectal Cancer | 16959974 | ENSP00000367910 | P429L | COSMIC | Lung Cancer | 20668451 | ENSP00000367910 | V471E | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| FANCG_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FANCG_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | FANCG_HUMAN | kinase -> substrate | RegPhos |
| CDK1_HUMAN | FANCG_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03460 | Fanconi anemia pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000160 | phosphorelay signal transduction system | IEA | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0007005 | mitochondrion organization | IMP | biological_process |
| GO:0001541 | ovarian follicle development | IEA | biological_process |
| GO:0006974 | response to DNA damage stimulus | IEA | biological_process |
| GO:0043240 | Fanconi anaemia nuclear complex | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0003684 | damaged DNA binding | TAS | molecular_function |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0007286 | spermatid development | IEA | biological_process |
| GO:0009314 | response to radiation | IEA | biological_process |