Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FA12_HUMAN
Description:coagulation factor XII (Hageman factor) [Source:HGNC Symbol;Acc:3530]
Location:chr5 q35.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y58YHRQLyHKCTHfn2PhosphoSitePlus
S366QRLRKsLSSMTPhosphoSitePlus
S243CQPWAsEATYRKringlePhosphoSitePlus
Y31PKEHKyKAEEHPhosphoSitePlus
T371SLSSMtRVVGGPhosphoSitePlus
Y53HFPFQyHRQLYfn2PhosphoSitePlus
S368LRKSLsSMTRVPhosphoSitePlus
T331QPTTRtPPQSQPhosphoSitePlus

Dephosphorylation site
FA12_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000253496E191KCOSMICSkin Cancer21984974

Differential expressed protein
FA12_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FA12_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HNF4A_HUMANFA12_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
FA12_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042730fibrinolysisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0016485protein processingIDAbiological_process
GO:0016540protein autoprocessingIDAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0007596blood coagulationIEAbiological_process
GO:0002353plasma kallikrein-kinin cascadeIDAbiological_process
GO:0051787misfolded protein bindingICmolecular_function
GO:0031638zymogen activationIDAbiological_process
GO:0004252serine-type endopeptidase activityIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0004252serine-type endopeptidase activityIDAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0070009serine-type aminopeptidase activityIEAmolecular_function
GO:0003824catalytic activityIEAmolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0030193regulation of blood coagulationIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0051788response to misfolded proteinIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0002542Factor XII activationIDAbiological_process
GO:0051919positive regulation of fibrinolysisIDAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0008233peptidase activityIEAmolecular_function
GO:0007597blood coagulation, intrinsic pathwayICbiological_process
GO:0030194positive regulation of blood coagulationIDAbiological_process
GO:0010756positive regulation of plasminogen activationIDAbiological_process


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