Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EREG_HUMAN
Description:epiregulin [Source:HGNC Symbol;Acc:3443]
Location:chr4 q13.3
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y144YFCRWyRNRKSPhosphoSitePlus

Dephosphorylation site
EREG_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000244869D46NCOSMICMelanoma21499247
ENSP00000244869G42ASjoblom2006, COSMIC, HPIBreast Cancer16959974

Differential expressed protein
EREG_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EREG_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EREG_HUMANEGFR_HUMANligand -> receptorHPMR
EREG_HUMANERBB4_HUMANotherKEGG
EREG_HUMANEGFR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042700luteinizing hormone signaling pathwayIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiTASbiological_process
GO:0048160primary follicle stageIEAbiological_process
GO:0005154epidermal growth factor receptor bindingISSmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0001525angiogenesisIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0030728ovulationIEAbiological_process
GO:0001819positive regulation of cytokine productionIEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0001556oocyte maturationISSbiological_process
GO:0007143female meiosisISSbiological_process
GO:0042060wound healingTASbiological_process
GO:0045410positive regulation of interleukin-6 biosynthetic ISSbiological_process
GO:0042108positive regulation of cytokine biosynthetic proceIDAbiological_process
GO:0045089positive regulation of innate immune responseISSbiological_process
GO:0045840positive regulation of mitosisIEAbiological_process
GO:0001550ovarian cumulus expansionISSbiological_process
GO:0045410positive regulation of interleukin-6 biosynthetic IEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042327positive regulation of phosphorylationIDAbiological_process
GO:0045860positive regulation of protein kinase activityIDAbiological_process
GO:0045741positive regulation of epidermal growth factor-actISSbiological_process
GO:0007267cell-cell signalingIDAbiological_process
GO:0001556oocyte maturationIEAbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0009299mRNA transcriptionIDAbiological_process
GO:0030728ovulationISSbiological_process
GO:0005154epidermal growth factor receptor bindingIEAmolecular_function
GO:0008284positive regulation of cell proliferationISSbiological_process
GO:0042700luteinizing hormone signaling pathwayISSbiological_process
GO:0048160primary follicle stageISSbiological_process
GO:0001550ovarian cumulus expansionIEAbiological_process
GO:0008285negative regulation of cell proliferationISSbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0030216keratinocyte differentiationTASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0045740positive regulation of DNA replicationISSbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0043616keratinocyte proliferationIDAbiological_process
GO:0009887organ morphogenesisTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0045089positive regulation of innate immune responseIEAbiological_process
GO:0048146positive regulation of fibroblast proliferationIDAbiological_process
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0051151negative regulation of smooth muscle cell differenIDAbiological_process
GO:0001819positive regulation of cytokine productionISSbiological_process
GO:0019221cytokine-mediated signaling pathwayIDAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayISSbiological_process
GO:0048661positive regulation of smooth muscle cell proliferISSbiological_process
GO:0045741positive regulation of epidermal growth factor-actIEAbiological_process
GO:0045840positive regulation of mitosisISSbiological_process
GO:0007143female meiosisIEAbiological_process