Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPN1_HUMAN
Description:epsin 1 [Source:HGNC Symbol;Acc:21604]
Location:chr19 q13.42
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T464ATPTPtPPTRKPhosphoSitePlus
T436PAATPtPTPPTHPRD
T467TPTPPtRKTPEPhosphoSitePlus
T470PPTRKtPESFLPhosphoSitePlus
S410EVPARsPGAFDphosphoELM; SysPTM
Y548GAPPTyISPLGPhosphoSitePlus
S435EVPARsPGAFDPhosphoSitePlus
T444PPTRKtPESFLHPRD
S420PTSGSsAGELEPhosphoSitePlus
S524PPTYIsPLGGGHPRD
S428AEAVGsPPPAAHPRD
Y111LKDFQyVDRDGENTHPhosphoSitePlus
T468SRPGPtPPGAKHPRD
S393LPTSGsSAGELHPRD
S357DPWGGsPAKPSCDC2(CDK1RegPhos
S357DPWGGsPAKPSCDK1HPRD; phosphoELM
S417GAFDMsGVRGSphosphoELM
S429AEAVGsPPPAAphosphoELM; SysPTM
T434PPPAAtPTPTPHPRD
S447SGVRGsLAEAVPhosphoSitePlus
S421SGVRGsLAEAVHPRD
Y16KNIVHnYSEAEHPRD
T494SRPGPtPPGAKPhosphoSitePlus
S454AEAVGsPPPAAPhosphoSitePlus
S382DPWGGsPAKPSPhosphoSitePlus
T437PAATPtPTPPTphosphoELM
S18IVHNYsEAEIKENTHPhosphoSitePlus
T469SRPGPtPPGAKphosphoELM; RegPhos; SysPTM
T416RTALPtSGSSAPhosphoSitePlus
S417TALPTsGSSAGPhosphoSitePlus
S357DPWGGsPAKPSCDC2RegPhos
T438ATPTPtPPTRKHPRD
S409EVPARsPGAFDHPRD
Y17NIVHNySEAEIENTHPhosphoSitePlus
S395PTSGSsAGELERegPhos
S416GAFDMsGVRGSHPRD
T460PPPAAtPTPTPPhosphoSitePlus
T439ATPTPtPPTRKphosphoELM
T521PGAPPtYISPLHPRD
S510NQLRLsPVPPVHPRD
T435PPPAAtPTPTPphosphoELM
S419LPTSGsSAGELPhosphoSitePlus
S460LVDLDsLVSRPHPRD
S394PTSGSsAGELEHPRD
S475PGAKAsNPFLPHPRD
S422GSLAEAVGSPPPAATPTPTPPTRSysPTM 2.0

Dephosphorylation site
EPN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000085079G34SBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000406209*663GCOSMICHead and Neck Cancer21798893

Differential expressed protein
EPN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EPN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANEPN1_HUMANkinase -> substrateRegPhos
CDK1_HUMANEPN1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006897endocytosisIEAbiological_process
GO:0007565female pregnancyIEAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005905coated pitIEAcellular_component
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0008289lipid bindingIEAmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0048568embryonic organ developmentIEAbiological_process


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