| UniProt/SwissProt ID: | EPN1_HUMAN |
| Description: | epsin 1 [Source:HGNC Symbol;Acc:21604] |
| Location: | chr19 q13.42 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T464 | ATPTPtPPTRK | PhosphoSitePlus | |
| T436 | PAATPtPTPPT | HPRD | |
| T467 | TPTPPtRKTPE | PhosphoSitePlus | |
| T470 | PPTRKtPESFL | PhosphoSitePlus | |
| S410 | EVPARsPGAFD | phosphoELM; SysPTM | |
| Y548 | GAPPTyISPLG | PhosphoSitePlus | |
| S435 | EVPARsPGAFD | PhosphoSitePlus | |
| T444 | PPTRKtPESFL | HPRD | |
| S420 | PTSGSsAGELE | PhosphoSitePlus | |
| S524 | PPTYIsPLGGG | HPRD | |
| S428 | AEAVGsPPPAA | HPRD | |
| Y111 | LKDFQyVDRDG | ENTH | PhosphoSitePlus |
| T468 | SRPGPtPPGAK | HPRD | |
| S393 | LPTSGsSAGEL | HPRD | |
| S357 | DPWGGsPAKPS | CDC2(CDK1 | RegPhos |
| S357 | DPWGGsPAKPS | CDK1 | HPRD; phosphoELM |
| S417 | GAFDMsGVRGS | phosphoELM | |
| S429 | AEAVGsPPPAA | phosphoELM; SysPTM | |
| T434 | PPPAAtPTPTP | HPRD | |
| S447 | SGVRGsLAEAV | PhosphoSitePlus | |
| S421 | SGVRGsLAEAV | HPRD | |
| Y16 | KNIVHnYSEAE | HPRD | |
| T494 | SRPGPtPPGAK | PhosphoSitePlus | |
| S454 | AEAVGsPPPAA | PhosphoSitePlus | |
| S382 | DPWGGsPAKPS | PhosphoSitePlus | |
| T437 | PAATPtPTPPT | phosphoELM | |
| S18 | IVHNYsEAEIK | ENTH | PhosphoSitePlus |
| T469 | SRPGPtPPGAK | phosphoELM; RegPhos; SysPTM | |
| T416 | RTALPtSGSSA | PhosphoSitePlus | |
| S417 | TALPTsGSSAG | PhosphoSitePlus | |
| S357 | DPWGGsPAKPS | CDC2 | RegPhos |
| T438 | ATPTPtPPTRK | HPRD | |
| S409 | EVPARsPGAFD | HPRD | |
| Y17 | NIVHNySEAEI | ENTH | PhosphoSitePlus |
| S395 | PTSGSsAGELE | RegPhos | |
| S416 | GAFDMsGVRGS | HPRD | |
| T460 | PPPAAtPTPTP | PhosphoSitePlus | |
| T439 | ATPTPtPPTRK | phosphoELM | |
| T521 | PGAPPtYISPL | HPRD | |
| S510 | NQLRLsPVPPV | HPRD | |
| T435 | PPPAAtPTPTP | phosphoELM | |
| S419 | LPTSGsSAGEL | PhosphoSitePlus | |
| S460 | LVDLDsLVSRP | HPRD | |
| S394 | PTSGSsAGELE | HPRD | |
| S475 | PGAKAsNPFLP | HPRD | |
| S422 | GSLAEAVGSPPPAATPTPTPPTR | SysPTM 2.0 | |
| Dephosphorylation site |
| EPN1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000085079 | G34S | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000406209 | *663G | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| EPN1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| EPN1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | EPN1_HUMAN | kinase -> substrate | RegPhos |
| CDK1_HUMAN | EPN1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006897 | endocytosis | IEA | biological_process |
| GO:0007565 | female pregnancy | IEA | biological_process |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005905 | coated pit | IEA | cellular_component |
| GO:0007219 | Notch signaling pathway | IEA | biological_process |
| GO:0008134 | transcription factor binding | IEA | molecular_function |
| GO:0008289 | lipid binding | IEA | molecular_function |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0042059 | negative regulation of epidermal growth factor rec | TAS | biological_process |
| GO:0048568 | embryonic organ development | IEA | biological_process |