Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPHA1_HUMAN
Description:EPH receptor A1 [Source:HGNC Symbol;Acc:3385]
Location:chr7 q35
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S811ASDVWsFGIVMPkinase_TyrPhosphoSitePlus
Y599LWLKPyVDLQAPhosphoSitePlus
T155ADQSFtIRDLVEphrin_lbdPhosphoSitePlus
T780DDFDGtYETQGPkinase_TyrPhosphoSitePlus
Y781DFDGTyETQGGHPRD; phosphoELM
T805HRIFTtASDVWPkinase_TyrPhosphoSitePlus
T892PHSLRtIANFDPhosphoSitePlus
S908RLPSLsGSDGIPhosphoSitePlus
S919PYRTVsEWLESSAM_1PhosphoSitePlus
S910PSLSGsDGIPYPhosphoSitePlus; HPRD
T783DGTYEtQGGKIPkinase_TyrPhosphoSitePlus
S153VAADQsFTIRDEphrin_lbdPhosphoSitePlus
S34TLMDTsKAQGEEphrin_lbdPhosphoSitePlus
T33VTLMDtSKAQGHPRD; phosphoELM
Y781DFDGTyETQGGPkinase_TyrPhosphoSitePlus
S34TLMDTsKAQGEHPRD; phosphoELM
S906TLRLPsLSGSDPhosphoSitePlus; HPRD
Y605VDLQAyEDPAQPhosphoSitePlus
T33VTLMDtSKAQGEphrin_lbdPhosphoSitePlus

Dephosphorylation site
EPHA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000275815L710PCOSMICOvarian Cancer21720365
ENSP00000275815R926GCOSMICOvarian Cancer21720365
ENSP00000275815R966CCOSMICOvarian Cancer21720365
ENSP00000275815E703KHPI, COSMICBreast Cancer17344846, 15908952
ENSP00000275815R337QDing2008, COSMICLung Cancer18948947

Differential expressed protein
EPHA1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EPHA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EFNA1_HUMANEPHA1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032862activation of Rho GTPase activityIDAbiological_process
GO:0001954positive regulation of cell-matrix adhesionIDAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0034446substrate adhesion-dependent cell spreadingIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0051496positive regulation of stress fiber assemblyISSbiological_process
GO:0045766positive regulation of angiogenesisIMPbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0005005transmembrane-ephrin receptor activityIDAmolecular_function
GO:0006469negative regulation of protein kinase activityIDAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0051496positive regulation of stress fiber assemblyIEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0030336negative regulation of cell migrationIDAbiological_process
GO:0048013ephrin receptor signaling pathwayIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0007166cell surface receptor signaling pathwayIDAbiological_process
GO:0032314regulation of Rac GTPase activityIDAbiological_process
GO:0005003ephrin receptor activityIEAmolecular_function