| UniProt/SwissProt ID: | ELMO1_HUMAN |
| Description: | engulfment and cell motility 1 [Source:HGNC Symbol;Acc:16286] |
| Location: | chr7 p14.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y720 | KEPSNyDFVYD | HCK | HPRD |
| Y395 | HHQDAyIRIVL | HCK | HPRD |
| Y216 | NSHDLyQKVAQ | DUF3361 | PhosphoSitePlus |
| Y395 | HHQDAyIRIVL | ELMO_CED12 | PhosphoSitePlus |
| S341 | SEPNNsSGSME | ELMO_CED12 | PhosphoSitePlus |
| Y18 | EWPGAyPKLME | PhosphoSitePlus; phosphoELM | |
| Y216 | NSHDLyQKVAQ | HCK | HPRD |
| Y240 | KEPSNyDFVYD | HPRD | |
| Y724 | NYDFVyD | HPRD | |
| Y216 | NSHDLyQKVAQ | phosphoELM | |
| Y720 | KEPSNyDFVYD | PhosphoSitePlus; phosphoELM | |
| Y724 | NYDFVyDCN__ | PhosphoSitePlus | |
| Y352 | KRKSMyTRDYK | ELMO_CED12 | PhosphoSitePlus |
| S350 | MEKRKsMYTRD | ELMO_CED12 | PhosphoSitePlus |
| S196 | SAIDIsILQRS | DUF3361 | PhosphoSitePlus |
| Y244 | NYDFVyD | HPRD | |
| T473 | KEMRAtSEDFN | ELMO_CED12 | PhosphoSitePlus |
| S718 | IPKEPsNYDFV | PhosphoSitePlus | |
| S344 | NNSSGsMEKRK | ELMO_CED12 | PhosphoSitePlus |
| Y18 | EWPGAyPKLME | HCK | HPRD |
| Y395 | HHQDAyIRIVL | phosphoELM | |
| Y511 | LQNLSyTEILK | PhosphoSitePlus; phosphoELM | |
| T466 | QLLNKtWKEMR | ELMO_CED12 | PhosphoSitePlus |
| Y511 | LQNLSyTEILK | HCK | HPRD |
| S342 | EPNNSsGSMEK | ELMO_CED12 | PhosphoSitePlus |
| Y140 | SGTERyQKLQK | DUF3361 | PhosphoSitePlus |
| T512 | QNLSYtEILKI | PhosphoSitePlus | |
| Dephosphorylation site |
| ELMO1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000312185 | F361L | COSMIC | Melanoma | 21499247 | ENSP00000312185 | S603F | COSMIC | Skin Cancer | 21984974 | ENSP00000379355 | *248K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000312185 | A99T | COSMIC | Melanoma | 21499247 | ENSP00000312185 | A5T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000379360 | *248K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000312185 | Q221* | COSMIC | Head and Neck Cancer | 21798897 |
| Differential expressed protein |
| ELMO1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ELMO1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HCK_HUMAN | ELMO1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05131 | Shigellosis |
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa04062 | Chemokine signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030036 | actin cytoskeleton organization | IGI | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0016601 | Rac protein signal transduction | IGI | biological_process |
| GO:0030029 | actin filament-based process | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0006915 | apoptotic process | NAS | biological_process |
| GO:0006911 | phagocytosis, engulfment | IGI | biological_process |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0006928 | cellular component movement | IGI | biological_process |
| GO:0017124 | SH3 domain binding | IPI | molecular_function |
| GO:0006909 | phagocytosis | IEA | biological_process |
| GO:0050690 | regulation of defense response to virus by virus | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |