Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ELMO1_HUMAN
Description:engulfment and cell motility 1 [Source:HGNC Symbol;Acc:16286]
Location:chr7 p14.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y720KEPSNyDFVYDHCKHPRD
Y395HHQDAyIRIVLHCKHPRD
Y216NSHDLyQKVAQDUF3361PhosphoSitePlus
Y395HHQDAyIRIVLELMO_CED12PhosphoSitePlus
S341SEPNNsSGSMEELMO_CED12PhosphoSitePlus
Y18EWPGAyPKLMEPhosphoSitePlus; phosphoELM
Y216NSHDLyQKVAQHCKHPRD
Y240KEPSNyDFVYDHPRD
Y724NYDFVyDHPRD
Y216NSHDLyQKVAQphosphoELM
Y720KEPSNyDFVYDPhosphoSitePlus; phosphoELM
Y724NYDFVyDCN__PhosphoSitePlus
Y352KRKSMyTRDYKELMO_CED12PhosphoSitePlus
S350MEKRKsMYTRDELMO_CED12PhosphoSitePlus
S196SAIDIsILQRSDUF3361PhosphoSitePlus
Y244NYDFVyDHPRD
T473KEMRAtSEDFNELMO_CED12PhosphoSitePlus
S718IPKEPsNYDFVPhosphoSitePlus
S344NNSSGsMEKRKELMO_CED12PhosphoSitePlus
Y18EWPGAyPKLMEHCKHPRD
Y395HHQDAyIRIVLphosphoELM
Y511LQNLSyTEILKPhosphoSitePlus; phosphoELM
T466QLLNKtWKEMRELMO_CED12PhosphoSitePlus
Y511LQNLSyTEILKHCKHPRD
S342EPNNSsGSMEKELMO_CED12PhosphoSitePlus
Y140SGTERyQKLQKDUF3361PhosphoSitePlus
T512QNLSYtEILKIPhosphoSitePlus

Dephosphorylation site
ELMO1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000312185F361LCOSMICMelanoma21499247
ENSP00000312185S603FCOSMICSkin Cancer21984974
ENSP00000379355*248KCOSMICHead and Neck Cancer21798893
ENSP00000312185A99TCOSMICMelanoma21499247
ENSP00000312185A5TCOSMICOvarian Cancer21720365
ENSP00000379360*248KCOSMICHead and Neck Cancer21798893
ENSP00000312185Q221*COSMICHead and Neck Cancer21798897

Differential expressed protein
ELMO1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ELMO1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HCK_HUMANELMO1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05131Shigellosis
hsa05100Bacterial invasion of epithelial cells
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0030036actin cytoskeleton organizationIGIbiological_process
GO:0005829cytosolTAScellular_component
GO:0016601Rac protein signal transductionIGIbiological_process
GO:0030029actin filament-based processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005488bindingIEAmolecular_function
GO:0006915apoptotic processNASbiological_process
GO:0006911phagocytosis, engulfmentIGIbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0016032viral reproductionTASbiological_process
GO:0006928cellular component movementIGIbiological_process
GO:0017124SH3 domain bindingIPImolecular_function
GO:0006909phagocytosisIEAbiological_process
GO:0050690regulation of defense response to virus by virusTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005737cytoplasmIDAcellular_component


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