Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EIF2A_HUMAN
Description:eukaryotic translation initiation factor 2A, 65kDa [Source:HGNC Symbol;Acc:3254]
Location:chr3 q25.1
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S517TPAPQsTPRNTPhosphoSitePlus; phosphoELM
Y446KVATAyRPPALPhosphoSitePlus
S526NTVSQsISGDPPhosphoSitePlus
T512PDLAPtPAPQSPhosphoSitePlus; phosphoELM
Y258EQTLHyIATNGeIF2APhosphoSitePlus
S503KQEARsDKSPDPhosphoSitePlus; phosphoELM
T361VASDStYFAWCeIF2APhosphoSitePlus
T9STPLLtVRGSEPhosphoSitePlus
Y428AKTITyQAVPSeIF2APhosphoSitePlus
S249DKTGAsYYGEQeIF2APhosphoSitePlus
Y251TGASYyGEQTLeIF2APhosphoSitePlus
S506ARSDKsPDLAPPhosphoSitePlus; phosphoELM
S4__MAPsTPLLTPhosphoSitePlus
T241LVIAStDVDKTeIF2APhosphoSitePlus
Y362ASDSTyFAWCPeIF2APhosphoSitePlus
T522STPRNtVSQSIPhosphoSitePlus; phosphoELM
S524PRNTVsQSISGPhosphoSitePlus
T518PAPQStPRNTVPhosphoSitePlus; phosphoELM
Y250KTGASyYGEQTeIF2APhosphoSitePlus

Dephosphorylation site
EIF2A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000417229C289FTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000417229Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineUp2.216319398

Hyperphosphorylation site
EIF2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NRF1_HUMANEIF2A_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
EIF2A_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042255ribosome assemblyIMPbiological_process
GO:0032933SREBP signaling pathwayIEAbiological_process
GO:0006417regulation of translationIMPbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005850eukaryotic translation initiation factor 2 complexIDAcellular_component
GO:0009967positive regulation of signal transductionIEAbiological_process
GO:0043022ribosome bindingIMPmolecular_function
GO:0000049tRNA bindingIMPmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0003743translation initiation factor activityIMPmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0006412translationIEAbiological_process


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