| UniProt/SwissProt ID: | EIF2A_HUMAN |
| Description: | eukaryotic translation initiation factor 2A, 65kDa [Source:HGNC Symbol;Acc:3254] |
| Location: | chr3 q25.1 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S517 | TPAPQsTPRNT | PhosphoSitePlus; phosphoELM | |
| Y446 | KVATAyRPPAL | PhosphoSitePlus | |
| S526 | NTVSQsISGDP | PhosphoSitePlus | |
| T512 | PDLAPtPAPQS | PhosphoSitePlus; phosphoELM | |
| Y258 | EQTLHyIATNG | eIF2A | PhosphoSitePlus |
| S503 | KQEARsDKSPD | PhosphoSitePlus; phosphoELM | |
| T361 | VASDStYFAWC | eIF2A | PhosphoSitePlus |
| T9 | STPLLtVRGSE | PhosphoSitePlus | |
| Y428 | AKTITyQAVPS | eIF2A | PhosphoSitePlus |
| S249 | DKTGAsYYGEQ | eIF2A | PhosphoSitePlus |
| Y251 | TGASYyGEQTL | eIF2A | PhosphoSitePlus |
| S506 | ARSDKsPDLAP | PhosphoSitePlus; phosphoELM | |
| S4 | __MAPsTPLLT | PhosphoSitePlus | |
| T241 | LVIAStDVDKT | eIF2A | PhosphoSitePlus |
| Y362 | ASDSTyFAWCP | eIF2A | PhosphoSitePlus |
| T522 | STPRNtVSQSI | PhosphoSitePlus; phosphoELM | |
| S524 | PRNTVsQSISG | PhosphoSitePlus | |
| T518 | PAPQStPRNTV | PhosphoSitePlus; phosphoELM | |
| Y250 | KTGASyYGEQT | eIF2A | PhosphoSitePlus |
| Dephosphorylation site |
| EIF2A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000417229 | C289F | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000417229 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Up | 2.2 | 16319398 |
| Hyperphosphorylation site |
| EIF2A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NRF1_HUMAN | EIF2A_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| EIF2A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042255 | ribosome assembly | IMP | biological_process |
| GO:0032933 | SREBP signaling pathway | IEA | biological_process |
| GO:0006417 | regulation of translation | IMP | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005850 | eukaryotic translation initiation factor 2 complex | IDA | cellular_component |
| GO:0009967 | positive regulation of signal transduction | IEA | biological_process |
| GO:0043022 | ribosome binding | IMP | molecular_function |
| GO:0000049 | tRNA binding | IMP | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003743 | translation initiation factor activity | IMP | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006412 | translation | IEA | biological_process |